Langerhans Cell Histiocytosis of the Temporal Bone

Daniel Thomas Ginat*, Daniel Johnson, Nicole A. Cipriani

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Langerhans cell histiocytosis involving the temporal bone region is uncommon and can resemble malignant neoplasms on imaging due to high cellularity. Although recognizing the presence of sharp margins with beveled-edges can be helpful, tissue sampling is often necessary for confirming the diagnosis. Cytology classically demonstrates kidney-bean shaped nuclei within the Langerhans cells and immunohistochemical staining is positive for S-100, peanut agglutinin (PNA), MHC class II, CD1a, and Langerin (CD 207). These features are exemplified in this sine qua non radiology–pathology correlation article.

Original languageEnglish (US)
Pages (from-to)209-212
Number of pages4
JournalHead and Neck Pathology
Issue number2
StatePublished - Jun 1 2016


  • CT
  • Cytology
  • Langerhans cell histiocytosis
  • MRI
  • Pathology
  • Temporal bone

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Otorhinolaryngology
  • Oncology


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