Langerhans Cell Histiocytosis of the Temporal Bone

Daniel Thomas Ginat; Daniel Johnson; Nicole A. Cipriani

doi:10.1007/s12105-015-0629-x

Langerhans Cell Histiocytosis of the Temporal Bone

Daniel Thomas Ginat^*, Daniel Johnson, Nicole A. Cipriani

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Langerhans cell histiocytosis involving the temporal bone region is uncommon and can resemble malignant neoplasms on imaging due to high cellularity. Although recognizing the presence of sharp margins with beveled-edges can be helpful, tissue sampling is often necessary for confirming the diagnosis. Cytology classically demonstrates kidney-bean shaped nuclei within the Langerhans cells and immunohistochemical staining is positive for S-100, peanut agglutinin (PNA), MHC class II, CD1a, and Langerin (CD 207). These features are exemplified in this sine qua non radiology–pathology correlation article.

Original language	English (US)
Pages (from-to)	209-212
Number of pages	4
Journal	Head and Neck Pathology
Volume	10
Issue number	2
DOIs	https://doi.org/10.1007/s12105-015-0629-x
State	Published - Jun 1 2016

Keywords

CT
Cytology
Langerhans cell histiocytosis
MRI
Pathology
Temporal bone

ASJC Scopus subject areas

Pathology and Forensic Medicine
Otorhinolaryngology
Oncology

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10.1007/s12105-015-0629-x

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title = "Langerhans Cell Histiocytosis of the Temporal Bone",

abstract = "Langerhans cell histiocytosis involving the temporal bone region is uncommon and can resemble malignant neoplasms on imaging due to high cellularity. Although recognizing the presence of sharp margins with beveled-edges can be helpful, tissue sampling is often necessary for confirming the diagnosis. Cytology classically demonstrates kidney-bean shaped nuclei within the Langerhans cells and immunohistochemical staining is positive for S-100, peanut agglutinin (PNA), MHC class II, CD1a, and Langerin (CD 207). These features are exemplified in this sine qua non radiology–pathology correlation article.",

keywords = "CT, Cytology, Langerhans cell histiocytosis, MRI, Pathology, Temporal bone",

author = "Ginat, {Daniel Thomas} and Daniel Johnson and Cipriani, {Nicole A.}",

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year = "2016",

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doi = "10.1007/s12105-015-0629-x",

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T1 - Langerhans Cell Histiocytosis of the Temporal Bone

AU - Ginat, Daniel Thomas

AU - Johnson, Daniel

AU - Cipriani, Nicole A.

PY - 2016/6/1

Y1 - 2016/6/1

N2 - Langerhans cell histiocytosis involving the temporal bone region is uncommon and can resemble malignant neoplasms on imaging due to high cellularity. Although recognizing the presence of sharp margins with beveled-edges can be helpful, tissue sampling is often necessary for confirming the diagnosis. Cytology classically demonstrates kidney-bean shaped nuclei within the Langerhans cells and immunohistochemical staining is positive for S-100, peanut agglutinin (PNA), MHC class II, CD1a, and Langerin (CD 207). These features are exemplified in this sine qua non radiology–pathology correlation article.

AB - Langerhans cell histiocytosis involving the temporal bone region is uncommon and can resemble malignant neoplasms on imaging due to high cellularity. Although recognizing the presence of sharp margins with beveled-edges can be helpful, tissue sampling is often necessary for confirming the diagnosis. Cytology classically demonstrates kidney-bean shaped nuclei within the Langerhans cells and immunohistochemical staining is positive for S-100, peanut agglutinin (PNA), MHC class II, CD1a, and Langerin (CD 207). These features are exemplified in this sine qua non radiology–pathology correlation article.

KW - CT

KW - Cytology

KW - Langerhans cell histiocytosis

KW - MRI

KW - Pathology

KW - Temporal bone

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JO - Head and Neck Pathology

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ER -

Langerhans Cell Histiocytosis of the Temporal Bone

Abstract

Keywords

ASJC Scopus subject areas

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