Language disorders in neurodegenerative diseases

Borna Bonakdarpour*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter


The goal of this chapter is to discuss neuroanatomy of normal language function, and review clinical evaluation and management of progressive aphasias. Systematic use of neuroimaging, laboratory work up, and pharmacological, neuromodulatory, and nonpharmacological interventions including speech-language therapy, and psychosocial remediation will be reviewed. Based on recent neuroimaging studies, language network is studied based on neuroanatomically distinct ventral and dorsal pathways. These pathways contribute to lexical and phonological/syntactic processing respectively. Gradual impairment in these pathways, in the absence of significant decline in other cognitive networks will result in syndromes of primary progressive aphasia (PPA). Meticulous evaluation of word comprehension, fluency and grammaticality, repetition, naming, reading and writing, helps with further subtyping PPA. Following formulation of the clinical syndrome, structural and functional neuroimaging (topographical or progression biomarkers) are helpful tools to further specify the clinical phenotype as a guide to determine the underlying neuropathological process. Currently analysis of the cerebrospinal fluid and amyloid positron emission tomography (PET) can help with diagnosis of the neuropathological process (etiologic or state biomarkers). Based on diagnosis of the underlying neuropathology decision regarding appropriate pharmacological intervention will be possible. Comprehensive management of PPA involves utilization of both pharmacological and non-pharmacological intervention which include speech-language therapy, and psychosocial remediations.

Original languageEnglish (US)
Title of host publicationProgressive Cognitive Impairment and its Neuropathologic Correlates
Editors Gliebus Peter
Place of PublicationHauppauge, NY
PublisherNova Science Publishers, Inc.
Number of pages37
ISBN (Electronic)9781634852975
ISBN (Print)9781634852210
StatePublished - Jan 1 2016

ASJC Scopus subject areas

  • Physics and Astronomy(all)

Fingerprint Dive into the research topics of 'Language disorders in neurodegenerative diseases'. Together they form a unique fingerprint.

Cite this