TY - JOUR
T1 - Lansoprazole compared with ranitidine for the treatment of nonerosive gastroesophageal reflux disease
AU - Richter, Joel E.
AU - Campbell, Donald R.
AU - Kahrilas, Peter J.
AU - Huang, Bidan
AU - Fludas, Cheryl
PY - 2000/6/26
Y1 - 2000/6/26
N2 - Background: Traditionally, proton pump inhibitors are used primarily for patients with esophagitis. However, patients with nonerosive reflux disease may also benefit from these powerful medications. Objective: To compare the safety and symptom relief efficacy of lansoprazole with ranitidine therapy and with placebo. Methods: In 2 randomized, double-blind, multicenter trials of 901 patients with symptomatic reflux disease, which was confirmed by endoscopy to be nonerosive, received lansoprazole, 15 or 30 mg once daily; ranitidine, 150 mg twice daily; or placebo for 8 weeks. Results: Analysis of daily diary data during the first 4 weeks and for the entire 8 weeks of treatment revealed that patients who were treated with either dosage of lansoprazole reported significantly (P<.05) lower percentages of days and nights with heartburn, less pain severity of both day and night heartburn, fewer days of antacid use, and smaller amounts of antacid use compared with patients who were treated with ranitidine or placebo. The incidence of possible or probable treatment-related adverse reactions was comparable among the treatment groups; abdominal pain and diarrhea were the most commonly reported adverse events. No statistically significant differences were noted between treatment groups in laboratory analyses. Conclusion: Lansoprazole therapy is more effective than standard dosages of ranitidine or placebo in- relieving symptoms in patients with endoscopically confirmed nonerosive reflux esophagitis.
AB - Background: Traditionally, proton pump inhibitors are used primarily for patients with esophagitis. However, patients with nonerosive reflux disease may also benefit from these powerful medications. Objective: To compare the safety and symptom relief efficacy of lansoprazole with ranitidine therapy and with placebo. Methods: In 2 randomized, double-blind, multicenter trials of 901 patients with symptomatic reflux disease, which was confirmed by endoscopy to be nonerosive, received lansoprazole, 15 or 30 mg once daily; ranitidine, 150 mg twice daily; or placebo for 8 weeks. Results: Analysis of daily diary data during the first 4 weeks and for the entire 8 weeks of treatment revealed that patients who were treated with either dosage of lansoprazole reported significantly (P<.05) lower percentages of days and nights with heartburn, less pain severity of both day and night heartburn, fewer days of antacid use, and smaller amounts of antacid use compared with patients who were treated with ranitidine or placebo. The incidence of possible or probable treatment-related adverse reactions was comparable among the treatment groups; abdominal pain and diarrhea were the most commonly reported adverse events. No statistically significant differences were noted between treatment groups in laboratory analyses. Conclusion: Lansoprazole therapy is more effective than standard dosages of ranitidine or placebo in- relieving symptoms in patients with endoscopically confirmed nonerosive reflux esophagitis.
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U2 - 10.1001/archinte.160.12.1803
DO - 10.1001/archinte.160.12.1803
M3 - Article
C2 - 10871974
AN - SCOPUS:0034717520
VL - 160
SP - 1803
EP - 1809
JO - Archives of internal medicine (Chicago, Ill. : 1908)
JF - Archives of internal medicine (Chicago, Ill. : 1908)
SN - 2168-6106
IS - 12
ER -