Lantibiotics as probes for phosphatidylethanolamine

Ming Zhao*

*Corresponding author for this work

Research output: Contribution to journalReview article

58 Scopus citations

Abstract

Phosphatidylethanolamine (PE) is a major component in the mammalian plasma membrane. It is present mainly in the inner leaflet of the membrane bilayer in a viable, typical mammalian cell. However, accumulating evidence indicates that a number of biological events involve PE externalization. For instance, PE is concentrated at the surface of cleavage furrow between mitotic daughter cells and is correlated with the dynamics of contractile ring. In apoptotic cells, PE is exposed to the cell surface, thus providing a molecular marker for detection. In addition, PE is a cofactor in the anticoagulant mechanism, and a distinct distribution profile of PE has been documented at the blood-endothelium interface. These recent discoveries were made possible using PE-specific probes derived from duramycin and cinnamycin, which are members of type B lantibiotics. This review provides an account on the features of these PE-specific lantibiotics in the context of molecular probes for the characterization of PE on a cellular and tissue level. According to the existing data, PE is likely a versatile chemical species that plays a role in the regulation of defined biological and physiological activities. The utilities of lantibiotic-based molecular probes will help accelerate the characterization of PE as an abundant, yet elusive membrane component.

Original languageEnglish (US)
Pages (from-to)1071-1079
Number of pages9
JournalAmino Acids
Volume41
Issue number5
DOIs
StatePublished - Nov 2011

Keywords

  • Anticoagulant
  • Apoptosis
  • Cinnamycin
  • Cytokinesis
  • Duramycin
  • Imaging probe
  • Phosphatidylethanolamine

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Lantibiotics as probes for phosphatidylethanolamine'. Together they form a unique fingerprint.

  • Cite this