Laparoscopic unilateral oophorectomy for ovarian tissue cryopreservation in children

Erin Rowell*, Kristine S. Corkum, Timothy B Lautz, Monica M Laronda, Amy Leanne Walz, Mary Beth Madonna, Barbara A. Lockart, Marleta Reynolds

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background/Purpose: Many survivors of childhood cancer will experience premature gonadal insufficiency or infertility as a consequence of their medical treatments. Ovarian tissue cryopreservation (OTC) remains an experimental means of fertility preservation with few reports focused on the surgical technique and postoperative outcomes for OTC in children. Methods: This is a single institution, retrospective review of OTC cases from January 2011 to December 2017. Children were eligible for OTC if they had a greater than 80% risk of premature ovarian insufficiency or infertility owing to their anticipated gonadotoxic medical treatment. Results: OTC was performed in 64 patients. Median age was 12 years old (range: 5 months–23 years). Nearly half (48%) of the patients were premenarchal. Laparoscopic unilateral oophorectomy was performed in 84% of patients. There were no surgical complications. In 76% of patients, OTC was performed in conjunction with an ancillary procedure. The majority (96%) of patients were discharged within 24 hours. Median time from operation to medical therapy was six days, with no unanticipated treatments delays attributable to OTC. Conclusions: Laparoscopic unilateral oophorectomy for OTC can be performed safely, in combination with other ancillary procedures, as an outpatient procedure without delaying medical therapy for children facing a fertility-threatening diagnosis or treatment. Level of Evidence: IV.

Original languageEnglish (US)
Pages (from-to)543-549
Number of pages7
JournalJournal of pediatric surgery
Volume54
Issue number3
DOIs
StatePublished - Mar 1 2019

Fingerprint

Cryopreservation
Ovariectomy
Infertility
Therapeutics
Fertility Preservation
Fertility
Survivors
Outpatients

Keywords

  • Children
  • Fertility preservation
  • Laparoscopy
  • Oophorectomy
  • Ovarian tissue cryopreservation

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

@article{c563eaba66f04a9885dc3547126959b7,
title = "Laparoscopic unilateral oophorectomy for ovarian tissue cryopreservation in children",
abstract = "Background/Purpose: Many survivors of childhood cancer will experience premature gonadal insufficiency or infertility as a consequence of their medical treatments. Ovarian tissue cryopreservation (OTC) remains an experimental means of fertility preservation with few reports focused on the surgical technique and postoperative outcomes for OTC in children. Methods: This is a single institution, retrospective review of OTC cases from January 2011 to December 2017. Children were eligible for OTC if they had a greater than 80{\%} risk of premature ovarian insufficiency or infertility owing to their anticipated gonadotoxic medical treatment. Results: OTC was performed in 64 patients. Median age was 12 years old (range: 5 months–23 years). Nearly half (48{\%}) of the patients were premenarchal. Laparoscopic unilateral oophorectomy was performed in 84{\%} of patients. There were no surgical complications. In 76{\%} of patients, OTC was performed in conjunction with an ancillary procedure. The majority (96{\%}) of patients were discharged within 24 hours. Median time from operation to medical therapy was six days, with no unanticipated treatments delays attributable to OTC. Conclusions: Laparoscopic unilateral oophorectomy for OTC can be performed safely, in combination with other ancillary procedures, as an outpatient procedure without delaying medical therapy for children facing a fertility-threatening diagnosis or treatment. Level of Evidence: IV.",
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author = "Erin Rowell and Corkum, {Kristine S.} and Lautz, {Timothy B} and Laronda, {Monica M} and Walz, {Amy Leanne} and Madonna, {Mary Beth} and Lockart, {Barbara A.} and Marleta Reynolds",
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Laparoscopic unilateral oophorectomy for ovarian tissue cryopreservation in children. / Rowell, Erin; Corkum, Kristine S.; Lautz, Timothy B; Laronda, Monica M; Walz, Amy Leanne; Madonna, Mary Beth; Lockart, Barbara A.; Reynolds, Marleta.

In: Journal of pediatric surgery, Vol. 54, No. 3, 01.03.2019, p. 543-549.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Laparoscopic unilateral oophorectomy for ovarian tissue cryopreservation in children

AU - Rowell, Erin

AU - Corkum, Kristine S.

AU - Lautz, Timothy B

AU - Laronda, Monica M

AU - Walz, Amy Leanne

AU - Madonna, Mary Beth

AU - Lockart, Barbara A.

AU - Reynolds, Marleta

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Background/Purpose: Many survivors of childhood cancer will experience premature gonadal insufficiency or infertility as a consequence of their medical treatments. Ovarian tissue cryopreservation (OTC) remains an experimental means of fertility preservation with few reports focused on the surgical technique and postoperative outcomes for OTC in children. Methods: This is a single institution, retrospective review of OTC cases from January 2011 to December 2017. Children were eligible for OTC if they had a greater than 80% risk of premature ovarian insufficiency or infertility owing to their anticipated gonadotoxic medical treatment. Results: OTC was performed in 64 patients. Median age was 12 years old (range: 5 months–23 years). Nearly half (48%) of the patients were premenarchal. Laparoscopic unilateral oophorectomy was performed in 84% of patients. There were no surgical complications. In 76% of patients, OTC was performed in conjunction with an ancillary procedure. The majority (96%) of patients were discharged within 24 hours. Median time from operation to medical therapy was six days, with no unanticipated treatments delays attributable to OTC. Conclusions: Laparoscopic unilateral oophorectomy for OTC can be performed safely, in combination with other ancillary procedures, as an outpatient procedure without delaying medical therapy for children facing a fertility-threatening diagnosis or treatment. Level of Evidence: IV.

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