Large fluctuations in body weight during young adulthood and twenty-fwe-year risk of coronary death in men

Peggy Hamm, Richard B. Shekelle*, Jeremiah Stamler

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

207 Scopus citations

Abstract

The hypothesis that large fluctuations in weight during young adulthood are associated with increased risk of coronary heart disease was investigated by comparing the 25-year mortality of three groups of middle-aged men with distinctly different patterns of self-reported weight during young adulthood: 98 men who reported large gains and large losses, 133 who reported large gains and no losses, and 178 who reported no substantial change in weight They were selected from a cohort of 2,107 men aged 40-56 years who participated in the Western Electric Study from 1957 through 1983. The 25-year crude risk of coronary death was 26% In the "gain and loss" group, 15% In the "gain only" group, 14% In the "no change" group, and 17% in the remaining 1,550 men. After adjusiment for age and major coronary risk factors, the relative risk of coronary death in the gain and loss group as compared with the no change group was 2.0 (95% confidence interval 1.2-3.5). Risk of death from cancer was highest in the gain only group, and risk of death from all causes combined was lowest in the no change group. These results support the concept that large changes in weight during young adulthood increase the risk of coronary disease and of cancer.

Original languageEnglish (US)
Pages (from-to)312-318
Number of pages7
JournalAmerican journal of epidemiology
Volume129
Issue number2
DOIs
StatePublished - Feb 1989

Keywords

  • Body weight
  • Coronary disease
  • Neoplasms

ASJC Scopus subject areas

  • Epidemiology

Fingerprint

Dive into the research topics of 'Large fluctuations in body weight during young adulthood and twenty-fwe-year risk of coronary death in men'. Together they form a unique fingerprint.

Cite this