TY - JOUR
T1 - Large-particle calcium hydroxylapatite injection for correction of facial wrinkles and depressions
AU - Alam, Murad
AU - Havey, Jillian
AU - Pace, Natalie
AU - Pongprutthipan, Marisa
AU - Yoo, Simon S
PY - 2011/7/1
Y1 - 2011/7/1
N2 - Background: Small-particle calcium hydroxylapatite (Radiesse, Merz, Frankfurt, Germany) is safe and effective for facial wrinkle reduction, and has medium-term persistence for this indication. There is patient demand for similar fillers that may be longer lasting. Objective: We sought to assess the safety and persistence of effect in vivo associated with use of large-particle calcium hydroxylapatite (Coaptite, Merz) for facial augmentation and wrinkle reduction. Methods: This was a case series of 3 patients injected with large-particle calcium hydroxylapatite. Results: Large-particle calcium hydroxylapatite appears to be effective and well tolerated for correction of facial depressions, including upper mid-cheek atrophy, nasolabial creases, and HIV-associated lipoatrophy. Adverse events included erythema and edema, and transient visibility of the injection sites. Treated patients, all of whom had received small-particle calcium hydroxylapatite correction before, noted improved persistence at 6 and 15 months with the large-particle injections as compared with prior small-particle injections. Limitations: This is a small case series, and there was no direct control to compare the persistence of small-particle versus large-particle correction. Conclusions: For facial wrinkle correction, large-particle calcium hydroxylapatite has a safety profile comparable with that of small-particle calcium hydroxylapatite. The large-particle variant may have longer persistence that may be useful in selected clinical circumstances.
AB - Background: Small-particle calcium hydroxylapatite (Radiesse, Merz, Frankfurt, Germany) is safe and effective for facial wrinkle reduction, and has medium-term persistence for this indication. There is patient demand for similar fillers that may be longer lasting. Objective: We sought to assess the safety and persistence of effect in vivo associated with use of large-particle calcium hydroxylapatite (Coaptite, Merz) for facial augmentation and wrinkle reduction. Methods: This was a case series of 3 patients injected with large-particle calcium hydroxylapatite. Results: Large-particle calcium hydroxylapatite appears to be effective and well tolerated for correction of facial depressions, including upper mid-cheek atrophy, nasolabial creases, and HIV-associated lipoatrophy. Adverse events included erythema and edema, and transient visibility of the injection sites. Treated patients, all of whom had received small-particle calcium hydroxylapatite correction before, noted improved persistence at 6 and 15 months with the large-particle injections as compared with prior small-particle injections. Limitations: This is a small case series, and there was no direct control to compare the persistence of small-particle versus large-particle correction. Conclusions: For facial wrinkle correction, large-particle calcium hydroxylapatite has a safety profile comparable with that of small-particle calcium hydroxylapatite. The large-particle variant may have longer persistence that may be useful in selected clinical circumstances.
KW - Coaptite
KW - HIV lipoatrophy
KW - calcium hydroxylapatite
KW - cheek augmentation
KW - facial augmentation
KW - fillers
KW - soft-tissue augmentation
KW - wrinkle reduction
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U2 - 10.1016/j.jaad.2010.12.018
DO - 10.1016/j.jaad.2010.12.018
M3 - Article
C2 - 21501888
AN - SCOPUS:79958865879
SN - 0190-9622
VL - 65
SP - 92
EP - 96
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology
IS - 1
ER -