Large-scale population study of human cell lines indicates that dosage compensation is virtually complete

Colette M. Johnston, Frances L. Lovell, Daniel A. Leongamornlert, Barbara Elaine Stranger, Emmanouil T. Dermitzakis, Mark T. Ross*

*Corresponding author for this work

Research output: Contribution to journalArticle

102 Scopus citations

Abstract

X chromosome inactivation in female mammals results in dosage compensation of X-linked gene products between the sexes. In humans there is evidence that a substantial proportion of genes escape from silencing. We have carried out a large-scale analysis of gene expression in lymphoblastoid cell lines from four human populations to determine the extent to which escape from X chromosome inactivation disrupts dosage compensation. We conclude that dosage compensation is virtually complete. Overall expression from the X chromosome is only slightly higher in females and can largely be accounted for by elevated female expression of approximately 5% of X-linked genes. We suggest that the potential contribution of escape from X chromosome inactivation to phenotypic differences between the sexes is more limited than previously believed.

Original languageEnglish (US)
Pages (from-to)88-98
Number of pages11
JournalPLoS genetics
Volume4
Issue number1
DOIs
StatePublished - Jan 2008

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics
  • Genetics(clinical)
  • Cancer Research

Fingerprint Dive into the research topics of 'Large-scale population study of human cell lines indicates that dosage compensation is virtually complete'. Together they form a unique fingerprint.

  • Cite this