Latent and Replicating Forms of Epstein-Barr Virus DNA in Lymphomas and Lymphoproliferative Diseases

Ben Z. Katz*, Nancy Raab-Traub, George Miller

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

162 Scopus citations


Epstein-Barr virus (EBV) is associated with lymphomas and lymphoproliférative diseases that occur mainly in immunocompromised patients, but the role EBV plays in their pathogenesis is unclear. The evidence linking EBV etiologically to these disorders includes the presence of EBV DNA and nuclear antigens in the lesions and serologic evidence that some patients with these lesions are experiencing primary or reactivated EBV infections. These syndromes may represent proliferation of cells latently infected with EBV, but the possibility of viral replication has not been rigorously studied. DNA extracted from biopsies of 35 lymphoproliférative diseases was probed with regions of the EBV genome capable of distinguishing circular, episomal DNA found in latency from linear, replicating EBV DNA. All samples contained restriction fragments characteristic of fused termini, indicative of circular, latent genomes. Thirteen samples contained additional restriction fragments diagnostic of linear EBV DNA. Therefore, replicating EBV DNA is found in -40% of EBV-associated lymphoproliférative disorders.

Original languageEnglish (US)
Pages (from-to)589-598
Number of pages10
JournalJournal of Infectious Diseases
Issue number4
StatePublished - Oct 1989

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases


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