Lateral Corticospinal Tract Damage Correlates With Motor Output in Incomplete Spinal Cord Injury

Andrew C. Smith; Kenneth A. Weber; Denise R. O'Dell; Todd B. Parrish; Marie Wasielewski; James M. Elliott

doi:10.1016/j.apmr.2017.10.002

Lateral Corticospinal Tract Damage Correlates With Motor Output in Incomplete Spinal Cord Injury

Andrew C. Smith^*, Kenneth A. Weber, Denise R. O'Dell, Todd B. Parrish, Marie Wasielewski, James M. Elliott

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Objective: To investigate the relationship between spinal cord damage and specific motor function in participants with incomplete spinal cord injury (iSCI). Design: Single-blinded, cross-sectional study design. Setting: University setting research laboratory. Participants: Individuals with chronic cervical iSCI (N=14; 1 woman, 13 men; average age ± SD, 43±12y). Interventions: Not applicable. Main Outcome Measures: Axial T2-weighted magnetic resonance imaging (MRI) of spinal cord damage was performed in 14 participants with iSCI. Each participant's damage was processed for total damage quantification, lateral corticospinal tract (LCST) and gracile fasciculus (GF) analysis. Plantarflexion and knee extension were quantified using an isokinetic dynamometer. Walking ability was assessed using a 6-minute walk test. Results: Total damage was correlated with plantarflexion, knee extension, and distance walked in 6 minutes. Right LCST damage was correlated with right plantarflexion and right knee extension, while left LCST damage was correlated with left-sided measures. Right and left GF damage was not correlated with the motor output measures. Conclusions: MRI measures of spinal cord damage were correlated to motor function, and this measure appears to have spatial specificity to descending tracts, which may offer prognostic value after SCI.

Original language	English (US)
Pages (from-to)	660-666
Number of pages	7
Journal	Archives of physical medicine and rehabilitation
Volume	99
Issue number	4
DOIs	https://doi.org/10.1016/j.apmr.2017.10.002
State	Published - Apr 2018

Funding

Supported by the National Institutes of Health (NIH award no. 1 R01HD079076-01A1; the NIH Extramural Loan Repayment Program for Clinical Researchers funded by the National Institute of Neurological Disorders and Stroke; the Foundation for Physical Therapy Promotion of Doctoral Studies programs; and the Interdisciplinary Research Training in Pain and Substance Use Disorders (grant no. T32DA035165) funded by the National Institute on Drug Abuse.

Keywords

Magnetic resonance imaging
Rehabilitation
Spinal cord injuries

ASJC Scopus subject areas

Physical Therapy, Sports Therapy and Rehabilitation
Rehabilitation

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10.1016/j.apmr.2017.10.002

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title = "Lateral Corticospinal Tract Damage Correlates With Motor Output in Incomplete Spinal Cord Injury",

abstract = "Objective: To investigate the relationship between spinal cord damage and specific motor function in participants with incomplete spinal cord injury (iSCI). Design: Single-blinded, cross-sectional study design. Setting: University setting research laboratory. Participants: Individuals with chronic cervical iSCI (N=14; 1 woman, 13 men; average age ± SD, 43±12y). Interventions: Not applicable. Main Outcome Measures: Axial T2-weighted magnetic resonance imaging (MRI) of spinal cord damage was performed in 14 participants with iSCI. Each participant's damage was processed for total damage quantification, lateral corticospinal tract (LCST) and gracile fasciculus (GF) analysis. Plantarflexion and knee extension were quantified using an isokinetic dynamometer. Walking ability was assessed using a 6-minute walk test. Results: Total damage was correlated with plantarflexion, knee extension, and distance walked in 6 minutes. Right LCST damage was correlated with right plantarflexion and right knee extension, while left LCST damage was correlated with left-sided measures. Right and left GF damage was not correlated with the motor output measures. Conclusions: MRI measures of spinal cord damage were correlated to motor function, and this measure appears to have spatial specificity to descending tracts, which may offer prognostic value after SCI.",

keywords = "Magnetic resonance imaging, Rehabilitation, Spinal cord injuries",

author = "Smith, {Andrew C.} and Weber, {Kenneth A.} and O'Dell, {Denise R.} and Parrish, {Todd B.} and Marie Wasielewski and Elliott, {James M.}",

note = "Publisher Copyright: {\textcopyright} 2017 American Congress of Rehabilitation Medicine",

year = "2018",

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AU - Parrish, Todd B.

AU - Wasielewski, Marie

AU - Elliott, James M.

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N2 - Objective: To investigate the relationship between spinal cord damage and specific motor function in participants with incomplete spinal cord injury (iSCI). Design: Single-blinded, cross-sectional study design. Setting: University setting research laboratory. Participants: Individuals with chronic cervical iSCI (N=14; 1 woman, 13 men; average age ± SD, 43±12y). Interventions: Not applicable. Main Outcome Measures: Axial T2-weighted magnetic resonance imaging (MRI) of spinal cord damage was performed in 14 participants with iSCI. Each participant's damage was processed for total damage quantification, lateral corticospinal tract (LCST) and gracile fasciculus (GF) analysis. Plantarflexion and knee extension were quantified using an isokinetic dynamometer. Walking ability was assessed using a 6-minute walk test. Results: Total damage was correlated with plantarflexion, knee extension, and distance walked in 6 minutes. Right LCST damage was correlated with right plantarflexion and right knee extension, while left LCST damage was correlated with left-sided measures. Right and left GF damage was not correlated with the motor output measures. Conclusions: MRI measures of spinal cord damage were correlated to motor function, and this measure appears to have spatial specificity to descending tracts, which may offer prognostic value after SCI.

AB - Objective: To investigate the relationship between spinal cord damage and specific motor function in participants with incomplete spinal cord injury (iSCI). Design: Single-blinded, cross-sectional study design. Setting: University setting research laboratory. Participants: Individuals with chronic cervical iSCI (N=14; 1 woman, 13 men; average age ± SD, 43±12y). Interventions: Not applicable. Main Outcome Measures: Axial T2-weighted magnetic resonance imaging (MRI) of spinal cord damage was performed in 14 participants with iSCI. Each participant's damage was processed for total damage quantification, lateral corticospinal tract (LCST) and gracile fasciculus (GF) analysis. Plantarflexion and knee extension were quantified using an isokinetic dynamometer. Walking ability was assessed using a 6-minute walk test. Results: Total damage was correlated with plantarflexion, knee extension, and distance walked in 6 minutes. Right LCST damage was correlated with right plantarflexion and right knee extension, while left LCST damage was correlated with left-sided measures. Right and left GF damage was not correlated with the motor output measures. Conclusions: MRI measures of spinal cord damage were correlated to motor function, and this measure appears to have spatial specificity to descending tracts, which may offer prognostic value after SCI.

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Lateral Corticospinal Tract Damage Correlates With Motor Output in Incomplete Spinal Cord Injury

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