Lateral hypothalamic self-stimulation pathways in Rattus norvegicus

Hwa Huang Yung Hwa Huang; Aryeh Routtenberg

doi:10.1016/0031-9384(71)90323-4

Lateral hypothalamic self-stimulation pathways in Rattus norvegicus

Hwa Huang Yung Hwa Huang^*, Aryeh Routtenberg

^*Corresponding author for this work

Psychology

Research output: Contribution to journal › Article › peer-review

54 Scopus citations

Abstract

Self-stimulation in lateral hypothalamus involves the activation of several ascending and descending fiber systems. In an effort to define these fiber systems, self-stimulation loci were studied with a single low current level and bipolar nichrome electrodes made with wire 78.7 μ dia. Prograde degeneration revealed by the Fink-Heimer technique and retrograde chromatolytic changes were described following lesions at self-stimulation sites. Neuronal activity following electrical stimulation of self-stimulation sites was also used to define the functional influence of these fiber systems. The relationship with the extrapyramidal system was emphasized, with convergent evidence suggesting an intimate relation between lateral hypothalamic neurons and those of substantia nigra, pars compacta.

Original language	English (US)
Pages (from-to)	419-424,IN7-IN12,425-432
Journal	Physiology and Behavior
Volume	7
Issue number	3
DOIs	https://doi.org/10.1016/0031-9384(71)90323-4
State	Published - Sep 1971

Keywords

Lateral hypothalamus
Rattus Norvegicus
Self-stimulation pathways

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

Access to Document

10.1016/0031-9384(71)90323-4

Cite this

@article{4060161db9a144b0bb2b62785d61f819,

title = "Lateral hypothalamic self-stimulation pathways in Rattus norvegicus",

abstract = "Self-stimulation in lateral hypothalamus involves the activation of several ascending and descending fiber systems. In an effort to define these fiber systems, self-stimulation loci were studied with a single low current level and bipolar nichrome electrodes made with wire 78.7 μ dia. Prograde degeneration revealed by the Fink-Heimer technique and retrograde chromatolytic changes were described following lesions at self-stimulation sites. Neuronal activity following electrical stimulation of self-stimulation sites was also used to define the functional influence of these fiber systems. The relationship with the extrapyramidal system was emphasized, with convergent evidence suggesting an intimate relation between lateral hypothalamic neurons and those of substantia nigra, pars compacta.",

keywords = "Lateral hypothalamus, Rattus Norvegicus, Self-stimulation pathways",

author = "{Yung Hwa Huang}, {Hwa Huang} and Aryeh Routtenberg",

note = "Funding Information: After a four-day postoperative recovery period the animals were allowed to bar press for brain stimulation in the Skinner boxes. This SS test continued for 12 consecutive days, one session/day, 15 rain/session. The greatest number of bar tThis report is based upon a dissertation submitted by the first author under the direction of the second author in partial fulfillment for the doctoral degree at Northwestern University. This research was supported by MH17255 to A.R. to whom reprint requests at the Department of Psychology, Northwestern University, Evanston, Illinois 60201, should he sent. aPresent Address: Department of Physiology, University of Western Ontario, London, Ontario, Canada.",

year = "1971",

month = sep,

doi = "10.1016/0031-9384(71)90323-4",

language = "English (US)",

volume = "7",

pages = "419--424,IN7--IN12,425--432",

journal = "Physiology and Behavior",

issn = "0031-9384",

publisher = "Elsevier Inc.",

number = "3",

}

TY - JOUR

T1 - Lateral hypothalamic self-stimulation pathways in Rattus norvegicus

AU - Yung Hwa Huang, Hwa Huang

AU - Routtenberg, Aryeh

N1 - Funding Information: After a four-day postoperative recovery period the animals were allowed to bar press for brain stimulation in the Skinner boxes. This SS test continued for 12 consecutive days, one session/day, 15 rain/session. The greatest number of bar tThis report is based upon a dissertation submitted by the first author under the direction of the second author in partial fulfillment for the doctoral degree at Northwestern University. This research was supported by MH17255 to A.R. to whom reprint requests at the Department of Psychology, Northwestern University, Evanston, Illinois 60201, should he sent. aPresent Address: Department of Physiology, University of Western Ontario, London, Ontario, Canada.

PY - 1971/9

Y1 - 1971/9

N2 - Self-stimulation in lateral hypothalamus involves the activation of several ascending and descending fiber systems. In an effort to define these fiber systems, self-stimulation loci were studied with a single low current level and bipolar nichrome electrodes made with wire 78.7 μ dia. Prograde degeneration revealed by the Fink-Heimer technique and retrograde chromatolytic changes were described following lesions at self-stimulation sites. Neuronal activity following electrical stimulation of self-stimulation sites was also used to define the functional influence of these fiber systems. The relationship with the extrapyramidal system was emphasized, with convergent evidence suggesting an intimate relation between lateral hypothalamic neurons and those of substantia nigra, pars compacta.

AB - Self-stimulation in lateral hypothalamus involves the activation of several ascending and descending fiber systems. In an effort to define these fiber systems, self-stimulation loci were studied with a single low current level and bipolar nichrome electrodes made with wire 78.7 μ dia. Prograde degeneration revealed by the Fink-Heimer technique and retrograde chromatolytic changes were described following lesions at self-stimulation sites. Neuronal activity following electrical stimulation of self-stimulation sites was also used to define the functional influence of these fiber systems. The relationship with the extrapyramidal system was emphasized, with convergent evidence suggesting an intimate relation between lateral hypothalamic neurons and those of substantia nigra, pars compacta.

KW - Lateral hypothalamus

KW - Rattus Norvegicus

KW - Self-stimulation pathways

UR - http://www.scopus.com/inward/record.url?scp=0015128865&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0015128865&partnerID=8YFLogxK

U2 - 10.1016/0031-9384(71)90323-4

DO - 10.1016/0031-9384(71)90323-4

M3 - Article

C2 - 4329576

AN - SCOPUS:0015128865

SN - 0031-9384

VL - 7

SP - 419-424,IN7-IN12,425-432

JO - Physiology and Behavior

JF - Physiology and Behavior

IS - 3

ER -

Lateral hypothalamic self-stimulation pathways in Rattus norvegicus

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this