Lateral ventricular size and drug-induced parkinsonism

Daniel J. Luchins; Herbert Jackman; Herbert Y. Meltzer

doi:10.1016/0165-1781(83)90083-5

Lateral ventricular size and drug-induced parkinsonism

Daniel J. Luchins^*, Herbert Jackman, Herbert Y. Meltzer

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Computed Tomography (CT) was used to assess lateral ventricular size in 20 psychiatric inpatients who had participated in at least 5 weeks of a fixed dose chlorpromazine (CPZ) trial. During treatment with CPZ, eight patients had required antiparkinsonian medication for treatment of rigidity. The ventricular brain ratio (VBR) of these eight patients was greater than that of either the 12 patients who did not require antiparkinsonian medication or a similarly aged control group of neurological patients, scanned for tension or migraine headaches. On the basis of these findings it is suggested that large lateral ventricular size may be associated with increased vulnerability to develop drug-induced parkinsonism.

Original language	English (US)
Pages (from-to)	9-16
Number of pages	8
Journal	Psychiatry Research
Volume	9
Issue number	1
DOIs	https://doi.org/10.1016/0165-1781(83)90083-5
State	Published - May 1983

Keywords

Computed tomography
antiparkinsonian medication
drug-induced parkinsonism
lateral ventricles
serum neuroleptic values

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0165-1781(83)90083-5

Cite this

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title = "Lateral ventricular size and drug-induced parkinsonism",

abstract = "Computed Tomography (CT) was used to assess lateral ventricular size in 20 psychiatric inpatients who had participated in at least 5 weeks of a fixed dose chlorpromazine (CPZ) trial. During treatment with CPZ, eight patients had required antiparkinsonian medication for treatment of rigidity. The ventricular brain ratio (VBR) of these eight patients was greater than that of either the 12 patients who did not require antiparkinsonian medication or a similarly aged control group of neurological patients, scanned for tension or migraine headaches. On the basis of these findings it is suggested that large lateral ventricular size may be associated with increased vulnerability to develop drug-induced parkinsonism.",

keywords = "Computed tomography, antiparkinsonian medication, drug-induced parkinsonism, lateral ventricles, serum neuroleptic values",

author = "Luchins, {Daniel J.} and Herbert Jackman and Meltzer, {Herbert Y.}",

note = "Funding Information: Acknowledgment. The research reported was supported in part by USPHS MH-30938. State of Illinois Department of Mental Health. and the University of Chicago Brain Research Foundation. Herbert Y. Meltz.er is recipient of USPHS RCSA MH-47808.",

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T1 - Lateral ventricular size and drug-induced parkinsonism

AU - Luchins, Daniel J.

AU - Jackman, Herbert

AU - Meltzer, Herbert Y.

N1 - Funding Information: Acknowledgment. The research reported was supported in part by USPHS MH-30938. State of Illinois Department of Mental Health. and the University of Chicago Brain Research Foundation. Herbert Y. Meltz.er is recipient of USPHS RCSA MH-47808.

PY - 1983/5

Y1 - 1983/5

N2 - Computed Tomography (CT) was used to assess lateral ventricular size in 20 psychiatric inpatients who had participated in at least 5 weeks of a fixed dose chlorpromazine (CPZ) trial. During treatment with CPZ, eight patients had required antiparkinsonian medication for treatment of rigidity. The ventricular brain ratio (VBR) of these eight patients was greater than that of either the 12 patients who did not require antiparkinsonian medication or a similarly aged control group of neurological patients, scanned for tension or migraine headaches. On the basis of these findings it is suggested that large lateral ventricular size may be associated with increased vulnerability to develop drug-induced parkinsonism.

AB - Computed Tomography (CT) was used to assess lateral ventricular size in 20 psychiatric inpatients who had participated in at least 5 weeks of a fixed dose chlorpromazine (CPZ) trial. During treatment with CPZ, eight patients had required antiparkinsonian medication for treatment of rigidity. The ventricular brain ratio (VBR) of these eight patients was greater than that of either the 12 patients who did not require antiparkinsonian medication or a similarly aged control group of neurological patients, scanned for tension or migraine headaches. On the basis of these findings it is suggested that large lateral ventricular size may be associated with increased vulnerability to develop drug-induced parkinsonism.

KW - Computed tomography

KW - antiparkinsonian medication

KW - drug-induced parkinsonism

KW - lateral ventricles

KW - serum neuroleptic values

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Lateral ventricular size and drug-induced parkinsonism

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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