Lateral ventricular size and drug-induced parkinsonism

Daniel J. Luchins*, Herbert Jackman, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

Computed Tomography (CT) was used to assess lateral ventricular size in 20 psychiatric inpatients who had participated in at least 5 weeks of a fixed dose chlorpromazine (CPZ) trial. During treatment with CPZ, eight patients had required antiparkinsonian medication for treatment of rigidity. The ventricular brain ratio (VBR) of these eight patients was greater than that of either the 12 patients who did not require antiparkinsonian medication or a similarly aged control group of neurological patients, scanned for tension or migraine headaches. On the basis of these findings it is suggested that large lateral ventricular size may be associated with increased vulnerability to develop drug-induced parkinsonism.

Original languageEnglish (US)
Pages (from-to)9-16
Number of pages8
JournalPsychiatry Research
Volume9
Issue number1
DOIs
StatePublished - May 1983

Keywords

  • Computed tomography
  • antiparkinsonian medication
  • drug-induced parkinsonism
  • lateral ventricles
  • serum neuroleptic values

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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