Lateralization on neuroimaging does not differentiate frontotemporal lobar degeneration from Alzheimer's disease

Anne M. Lipton; Raul Benavides; Linda S. Hynan; Frederick J. Bonte; Thomas S. Harris; Charles L. White; Eileen H. Bigio

doi:10.1159/000077164

Lateralization on neuroimaging does not differentiate frontotemporal lobar degeneration from Alzheimer's disease

Anne M. Lipton^*, Raul Benavides, Linda S. Hynan, Frederick J. Bonte, Thomas S. Harris, Charles L. White, Eileen H. Bigio

^*Corresponding author for this work

Pathology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Lateralization on neuroimaging was compared in cases of frontotemporal lobar degeneration (FTLD; n = 10) and cases of definite Alzheimer's disease (AD; n = 17). All of the cases were pathologically confirmed and semi-quantitative and statistical parametric mapping methods were employed. Seven of the 10 FTLD cases had lateralization on at least one neuroimaging modality: single photon emission computerized tomography (SPECT), MRI, or CT. All 6/6 FTLD cases with SPECT showed lateralization. MRI results generally agreed with SPECT findings. Three of 4 FTLD cases had lateralized atrophy on CT. For the AD cases, 10/17 SPECTs, 2/7 MRIs, and 1/9 CTs showed lateralized findings. Of the neuroimaging modalities utilized, SPECT was the most sensitive in detecting lateralization.

Original language	English (US)
Pages (from-to)	324-327
Number of pages	4
Journal	Dementia and Geriatric Cognitive Disorders
Volume	17
Issue number	4
DOIs	https://doi.org/10.1159/000077164
State	Published - 2004

Keywords

Dementia
Frontotemporal dementia
Frontotemporal lobar degeneration
Single photon emission computerized tomography

ASJC Scopus subject areas

Geriatrics and Gerontology
Cognitive Neuroscience
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1159/000077164

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title = "Lateralization on neuroimaging does not differentiate frontotemporal lobar degeneration from Alzheimer's disease",

abstract = "Lateralization on neuroimaging was compared in cases of frontotemporal lobar degeneration (FTLD; n = 10) and cases of definite Alzheimer's disease (AD; n = 17). All of the cases were pathologically confirmed and semi-quantitative and statistical parametric mapping methods were employed. Seven of the 10 FTLD cases had lateralization on at least one neuroimaging modality: single photon emission computerized tomography (SPECT), MRI, or CT. All 6/6 FTLD cases with SPECT showed lateralization. MRI results generally agreed with SPECT findings. Three of 4 FTLD cases had lateralized atrophy on CT. For the AD cases, 10/17 SPECTs, 2/7 MRIs, and 1/9 CTs showed lateralized findings. Of the neuroimaging modalities utilized, SPECT was the most sensitive in detecting lateralization.",

keywords = "Dementia, Frontotemporal dementia, Frontotemporal lobar degeneration, Single photon emission computerized tomography",

author = "Lipton, {Anne M.} and Raul Benavides and Hynan, {Linda S.} and Bonte, {Frederick J.} and Harris, {Thomas S.} and White, {Charles L.} and Bigio, {Eileen H.}",

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T1 - Lateralization on neuroimaging does not differentiate frontotemporal lobar degeneration from Alzheimer's disease

AU - Lipton, Anne M.

AU - Benavides, Raul

AU - Hynan, Linda S.

AU - Bonte, Frederick J.

AU - Harris, Thomas S.

AU - White, Charles L.

AU - Bigio, Eileen H.

PY - 2004

Y1 - 2004

N2 - Lateralization on neuroimaging was compared in cases of frontotemporal lobar degeneration (FTLD; n = 10) and cases of definite Alzheimer's disease (AD; n = 17). All of the cases were pathologically confirmed and semi-quantitative and statistical parametric mapping methods were employed. Seven of the 10 FTLD cases had lateralization on at least one neuroimaging modality: single photon emission computerized tomography (SPECT), MRI, or CT. All 6/6 FTLD cases with SPECT showed lateralization. MRI results generally agreed with SPECT findings. Three of 4 FTLD cases had lateralized atrophy on CT. For the AD cases, 10/17 SPECTs, 2/7 MRIs, and 1/9 CTs showed lateralized findings. Of the neuroimaging modalities utilized, SPECT was the most sensitive in detecting lateralization.

AB - Lateralization on neuroimaging was compared in cases of frontotemporal lobar degeneration (FTLD; n = 10) and cases of definite Alzheimer's disease (AD; n = 17). All of the cases were pathologically confirmed and semi-quantitative and statistical parametric mapping methods were employed. Seven of the 10 FTLD cases had lateralization on at least one neuroimaging modality: single photon emission computerized tomography (SPECT), MRI, or CT. All 6/6 FTLD cases with SPECT showed lateralization. MRI results generally agreed with SPECT findings. Three of 4 FTLD cases had lateralized atrophy on CT. For the AD cases, 10/17 SPECTs, 2/7 MRIs, and 1/9 CTs showed lateralized findings. Of the neuroimaging modalities utilized, SPECT was the most sensitive in detecting lateralization.

KW - Dementia

KW - Frontotemporal dementia

KW - Frontotemporal lobar degeneration

KW - Single photon emission computerized tomography

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Lateralization on neuroimaging does not differentiate frontotemporal lobar degeneration from Alzheimer's disease

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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