Lattice Corneal Dystrophy Type IIIA: Clinical and Histopathologic Correlations

E. Lee Stock*, Robert S. Feder, Richard B. O'grady, Joel Sugar, Sanford I. Roth

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


All three types of lattice corneal dystrophy are inherited and localized, and they largely involve linear corneal amyloid deposits. We encountered two white families with lattice corneal dystrophy which closely resembled type III. Four generations of one family and three of another family exhibited lattice corneal dystrophy. Because both families are from Caccamo, Sicily, Italy, we believe it is likely that both are from a single mutation. Thick, ropy lattice lines were seen to traverse the corneas almost from limbus to limbus and were easily detected with direct illumination. Histopathologic examination revealed accumulations of varying sized amyloid deposits in the stroma and ribbons of amyloid between the stroma and Bowman's layer typical of lattice corneal dystrophy type III. We have named the disease in this family lattice corneal dystrophy type IIIA, because of three differences from lattice corneal dystrophy type III: the presence of corneal erosions, the occurrence in whites, and the autosomal dominant inheritance pattern.

Original languageEnglish (US)
Pages (from-to)354-358
Number of pages5
JournalArchives of ophthalmology
Issue number3
StatePublished - Mar 1991

ASJC Scopus subject areas

  • Ophthalmology


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