LDHC: The ultimate testis-specific gene

Erwin Goldberg*, Edward M. Eddy, Chongwen Duan, Fanny Odet

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

70 Scopus citations


Lactate dehydrogenase C (LDHC) was, to the best of our knowledge, the first testis-specific isozyme discovered in male germ cells. In fact, this was accomplished shortly before "isozymes or isoenzymes" became a field of study. LDHC was detected initially in human spermatozoa and spermatogenic cells of the testes by gel electrophoresis. Immunohistochemistry was used to localize LDHC first in early-pachytene primary spermatocytes, with an apparent increase in quantity after meiosis, to its final localization in and on the principal piece of the sperm tail. After several decades of biologic, biochemical, and genetic investigations, we now know that the lactate dehydrogenase isozymes are ubiquitous in vertebrates, developmentally regulated, tissue and cell specific, and multifunctional. Here, we will review the history of LDHC and the work that demonstrates clearly that it is required for sperm to accomplish their ultimate goal, fertilization.

Original languageEnglish (US)
Pages (from-to)86-94
Number of pages9
JournalJournal of andrology
Issue number1
StatePublished - Jan 2010


  • Glycolysis
  • Lactate dehydrogenase C
  • Male fertility
  • Sperm

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Endocrinology
  • Urology

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