Learning and aging affect neuronal excitability and learning

M. Matthew Oh, John F. Disterhoft*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

The first study that demonstrated a change in intrinsic neuronal excitability after learning in ex vivo brain tissue slices from a mammal was published over thirty years ago. Numerous other manuscripts describing similar learning-related changes have followed over the years since the original paper demonstrating the postburst afterhyperpolarization (AHP) reduction in CA1 pyramidal neurons from rabbits that learned delay eyeblink conditioning was published. In addition to the learning-related changes, aging-related enlargement of the postburst AHP in CA1 pyramidal neurons have been reported. Extensive work has been done relating slow afterhyperpolarization enhancement in CA1 hippocampus to slowed learning in some aging animals. These reproducible findings strongly implicate modulation of the postburst AHP as an essential cellular mechanism necessary for successful learning, at least in learning tasks that engage CA1 hippocampal pyramidal neurons.

Original languageEnglish (US)
Article number107133
JournalNeurobiology of Learning and Memory
Volume167
DOIs
StatePublished - Jan 2020

Fingerprint

Learning
Pyramidal Cells
Manuscripts
Mammals
Hippocampus
Rabbits
Brain

Keywords

  • Calcium
  • CREB
  • Eyeblink conditioning
  • Protein kinase
  • Water maze

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience

Cite this

@article{a8dffb0167b34a5c805c605979e26b6d,
title = "Learning and aging affect neuronal excitability and learning",
abstract = "The first study that demonstrated a change in intrinsic neuronal excitability after learning in ex vivo brain tissue slices from a mammal was published over thirty years ago. Numerous other manuscripts describing similar learning-related changes have followed over the years since the original paper demonstrating the postburst afterhyperpolarization (AHP) reduction in CA1 pyramidal neurons from rabbits that learned delay eyeblink conditioning was published. In addition to the learning-related changes, aging-related enlargement of the postburst AHP in CA1 pyramidal neurons have been reported. Extensive work has been done relating slow afterhyperpolarization enhancement in CA1 hippocampus to slowed learning in some aging animals. These reproducible findings strongly implicate modulation of the postburst AHP as an essential cellular mechanism necessary for successful learning, at least in learning tasks that engage CA1 hippocampal pyramidal neurons.",
keywords = "Calcium, CREB, Eyeblink conditioning, Protein kinase, Water maze",
author = "Oh, {M. Matthew} and Disterhoft, {John F.}",
year = "2020",
month = "1",
doi = "10.1016/j.nlm.2019.107133",
language = "English (US)",
volume = "167",
journal = "Neurobiology of Learning and Memory",
issn = "1074-7427",
publisher = "Academic Press Inc.",

}

Learning and aging affect neuronal excitability and learning. / Oh, M. Matthew; Disterhoft, John F.

In: Neurobiology of Learning and Memory, Vol. 167, 107133, 01.2020.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Learning and aging affect neuronal excitability and learning

AU - Oh, M. Matthew

AU - Disterhoft, John F.

PY - 2020/1

Y1 - 2020/1

N2 - The first study that demonstrated a change in intrinsic neuronal excitability after learning in ex vivo brain tissue slices from a mammal was published over thirty years ago. Numerous other manuscripts describing similar learning-related changes have followed over the years since the original paper demonstrating the postburst afterhyperpolarization (AHP) reduction in CA1 pyramidal neurons from rabbits that learned delay eyeblink conditioning was published. In addition to the learning-related changes, aging-related enlargement of the postburst AHP in CA1 pyramidal neurons have been reported. Extensive work has been done relating slow afterhyperpolarization enhancement in CA1 hippocampus to slowed learning in some aging animals. These reproducible findings strongly implicate modulation of the postburst AHP as an essential cellular mechanism necessary for successful learning, at least in learning tasks that engage CA1 hippocampal pyramidal neurons.

AB - The first study that demonstrated a change in intrinsic neuronal excitability after learning in ex vivo brain tissue slices from a mammal was published over thirty years ago. Numerous other manuscripts describing similar learning-related changes have followed over the years since the original paper demonstrating the postburst afterhyperpolarization (AHP) reduction in CA1 pyramidal neurons from rabbits that learned delay eyeblink conditioning was published. In addition to the learning-related changes, aging-related enlargement of the postburst AHP in CA1 pyramidal neurons have been reported. Extensive work has been done relating slow afterhyperpolarization enhancement in CA1 hippocampus to slowed learning in some aging animals. These reproducible findings strongly implicate modulation of the postburst AHP as an essential cellular mechanism necessary for successful learning, at least in learning tasks that engage CA1 hippocampal pyramidal neurons.

KW - Calcium

KW - CREB

KW - Eyeblink conditioning

KW - Protein kinase

KW - Water maze

UR - http://www.scopus.com/inward/record.url?scp=85076467856&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85076467856&partnerID=8YFLogxK

U2 - 10.1016/j.nlm.2019.107133

DO - 10.1016/j.nlm.2019.107133

M3 - Article

C2 - 31786311

AN - SCOPUS:85076467856

VL - 167

JO - Neurobiology of Learning and Memory

JF - Neurobiology of Learning and Memory

SN - 1074-7427

M1 - 107133

ER -