Learning and aging affect neuronal excitability and learning

M. Matthew Oh, John F. Disterhoft*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The first study that demonstrated a change in intrinsic neuronal excitability after learning in ex vivo brain tissue slices from a mammal was published over thirty years ago. Numerous other manuscripts describing similar learning-related changes have followed over the years since the original paper demonstrating the postburst afterhyperpolarization (AHP) reduction in CA1 pyramidal neurons from rabbits that learned delay eyeblink conditioning was published. In addition to the learning-related changes, aging-related enlargement of the postburst AHP in CA1 pyramidal neurons have been reported. Extensive work has been done relating slow afterhyperpolarization enhancement in CA1 hippocampus to slowed learning in some aging animals. These reproducible findings strongly implicate modulation of the postburst AHP as an essential cellular mechanism necessary for successful learning, at least in learning tasks that engage CA1 hippocampal pyramidal neurons.

Original languageEnglish (US)
Article number107133
JournalNeurobiology of Learning and Memory
StatePublished - Jan 2020


  • CREB
  • Calcium
  • Eyeblink conditioning
  • Protein kinase
  • Water maze

ASJC Scopus subject areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience
  • Behavioral Neuroscience


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