Abstract
Objective - To assess the degree of learning ability in Parkinson's disease. Methods - Three different learning tasks: eyeblink classical conditioning with delay and trace paradigms, the California verbal learning test (CVLT), and a serial reaction time task (SRTT) were studied in patients with Parkinson's disease and normal (control) subjects. Results - In the eyeblink conditioning tasks, both patients and normal subjects showed significant learning effects without between group differences. In the CVLT, patients remembered significantly fewer words than normal subjects in both short term and long term cued recall tasks. In the SRTT, normal subjects had significantly reduced response time and error rates across blocks of repeated sequence trials, whereas patients had significantly reduced error, but not response time rates. Conclusion - Impairment of nigrostriatal pathways selectively affects performance in complex learning tasks that are competitive and require alertness such as the SRTT, but not in simple learning procedures such as eyeblink conditioning.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 27-34 |
| Number of pages | 8 |
| Journal | Journal of Neurology Neurosurgery and Psychiatry |
| Volume | 67 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 1999 |
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Keywords
- Eyeblink classical conditioning
- Implicit and explicit memory
- Parkinson's disease
ASJC Scopus subject areas
- Surgery
- Clinical Neurology
- Psychiatry and Mental health
Cite this
}
Learning in Parkinson's disease : Eyeblink conditioning, declarative learning, and procedural learning. / Sommer, Martin; Grafman, Jordan; Clark, Kim; Hallett, Mark.
In: Journal of Neurology Neurosurgery and Psychiatry, Vol. 67, No. 1, 01.01.1999, p. 27-34.Research output: Contribution to journal › Article
TY - JOUR
T1 - Learning in Parkinson's disease
T2 - Eyeblink conditioning, declarative learning, and procedural learning
AU - Sommer, Martin
AU - Grafman, Jordan
AU - Clark, Kim
AU - Hallett, Mark
PY - 1999/1/1
Y1 - 1999/1/1
N2 - Objective - To assess the degree of learning ability in Parkinson's disease. Methods - Three different learning tasks: eyeblink classical conditioning with delay and trace paradigms, the California verbal learning test (CVLT), and a serial reaction time task (SRTT) were studied in patients with Parkinson's disease and normal (control) subjects. Results - In the eyeblink conditioning tasks, both patients and normal subjects showed significant learning effects without between group differences. In the CVLT, patients remembered significantly fewer words than normal subjects in both short term and long term cued recall tasks. In the SRTT, normal subjects had significantly reduced response time and error rates across blocks of repeated sequence trials, whereas patients had significantly reduced error, but not response time rates. Conclusion - Impairment of nigrostriatal pathways selectively affects performance in complex learning tasks that are competitive and require alertness such as the SRTT, but not in simple learning procedures such as eyeblink conditioning.
AB - Objective - To assess the degree of learning ability in Parkinson's disease. Methods - Three different learning tasks: eyeblink classical conditioning with delay and trace paradigms, the California verbal learning test (CVLT), and a serial reaction time task (SRTT) were studied in patients with Parkinson's disease and normal (control) subjects. Results - In the eyeblink conditioning tasks, both patients and normal subjects showed significant learning effects without between group differences. In the CVLT, patients remembered significantly fewer words than normal subjects in both short term and long term cued recall tasks. In the SRTT, normal subjects had significantly reduced response time and error rates across blocks of repeated sequence trials, whereas patients had significantly reduced error, but not response time rates. Conclusion - Impairment of nigrostriatal pathways selectively affects performance in complex learning tasks that are competitive and require alertness such as the SRTT, but not in simple learning procedures such as eyeblink conditioning.
KW - Eyeblink classical conditioning
KW - Implicit and explicit memory
KW - Parkinson's disease
UR - http://www.scopus.com/inward/record.url?scp=0033002881&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033002881&partnerID=8YFLogxK
U2 - 10.1136/jnnp.67.1.27
DO - 10.1136/jnnp.67.1.27
M3 - Article
VL - 67
SP - 27
EP - 34
JO - Journal of Neurology, Neurosurgery and Psychiatry
JF - Journal of Neurology, Neurosurgery and Psychiatry
SN - 0022-3050
IS - 1
ER -