Learning increases intrinsic excitability of hippocampal interneurons

Bridget M. Mckay, M Matthew Oh, John F Disterhoft

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Learning-related intrinsic excitability changes of pyramidal neurons via modulation of the postburst afterhyperpolarization (AHP)havebeenrepeatedlydemonstratedinmultiplebrainregions(especiallythehippocampus),afteravarietyoflearningtasks, and in multiple species. While exciting and important, the changes in pyramidal neurons are only a part of the neural circuitry involved in successful learning. For a more complete picture of the dynamic learning-related changes in the neural network, changesininhibitorycircuitrymustalsobesystematicallyexaminedandcharacterized.Hereweshowinyoungadultratsandmice that learning the hippocampus-dependent trace eyeblink conditioning task induces enhanced inhibition onto CA1 pyramidal neurons mediated, in part, by an increase in intrinsic excitability of somatostatin-positive inhibitory neurons (SOMs). Furthermore, both CA1 pyramidal and SOM interneurons shared a common cellular mechanism (reduction in SK channel-mediated AHP) that led to the learning-induced increased intrinsic excitability.

Original languageEnglish (US)
Pages (from-to)5499-5506
Number of pages8
JournalJournal of Neuroscience
Volume33
Issue number13
DOIs
StatePublished - Mar 27 2013

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Interneurons
Learning
Pyramidal Cells
Somatostatin
Hippocampus
Neurons

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

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abstract = "Learning-related intrinsic excitability changes of pyramidal neurons via modulation of the postburst afterhyperpolarization (AHP)havebeenrepeatedlydemonstratedinmultiplebrainregions(especiallythehippocampus),afteravarietyoflearningtasks, and in multiple species. While exciting and important, the changes in pyramidal neurons are only a part of the neural circuitry involved in successful learning. For a more complete picture of the dynamic learning-related changes in the neural network, changesininhibitorycircuitrymustalsobesystematicallyexaminedandcharacterized.Hereweshowinyoungadultratsandmice that learning the hippocampus-dependent trace eyeblink conditioning task induces enhanced inhibition onto CA1 pyramidal neurons mediated, in part, by an increase in intrinsic excitability of somatostatin-positive inhibitory neurons (SOMs). Furthermore, both CA1 pyramidal and SOM interneurons shared a common cellular mechanism (reduction in SK channel-mediated AHP) that led to the learning-induced increased intrinsic excitability.",
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Learning increases intrinsic excitability of hippocampal interneurons. / Mckay, Bridget M.; Oh, M Matthew; Disterhoft, John F.

In: Journal of Neuroscience, Vol. 33, No. 13, 27.03.2013, p. 5499-5506.

Research output: Contribution to journalArticle

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