Left Atrial Decompression Pump for Severe Heart Failure With Preserved Ejection Fraction: Theoretical and Clinical Considerations

Daniel Burkhoff*, Mathew S. Maurer, Susan M. Joseph, Joseph G. Rogers, Edo Y. Birati, J. Eduardo Rame, Sanjiv J. Shah

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Objectives: The purpose of this study was to provide insight into the potential for left atrium (LA) to aortic mechanical circulatory support as a treatment for patients with heart failure with preserved ejection fraction (HFpEF). Background: Although HFpEF arises from different etiologies, 1hallmark of all forms of this syndrome is a small or minimally-dilated left ventricle (LV). Consequently, the use of traditional mechanical circulatory support in end-stage patients has been difficult. In contrast, HFpEF is also characterized by a large LA. Methods: Hemodynamic characteristics of 4 distinct HFpEF phenotypes were characterized from the published data: 1)hypertrophic cardiomyopathies; 2) infiltrative diseases; 3) nonhypertrophic HFpEF; and 4) HFpEF with common cardiovascular comorbidities (e.g., hypertension). Employing a previously-described cardiovascular simulation, the effects ofa low-flow, micropump-based LA decompression device were modeled. The effect of sourcing blood from the LV versus the LA was compared. Results: For all HFpEF phenotypes, mechanical circulatory support significantly increased cardiac output, provided a mild increase in blood pressure, and markedly reduced pulmonary and LA pressures. LV sourcing of blood reduced LV end-systolic volume into a range likely to induce suction. With LA sourcing, however, LV end-systolic volume increased compared with baseline. Due to pre-existing LA enlargement, LA volumes remained sufficiently elevated, thus minimizing the risk of suction. Conclusions: This theoretical analysis suggests that a strategy involving pumping blood from the LA to the arterial system may provide a viable option for end-stage HFpEF. Special considerations apply to each of the 4 types of HFpEFphenotypes described. Finally, an HFpEF-specific clinical profile scoring system (such as that of INTERMACS [Interagency Registry for Mechanically Assisted Circulatory Support]) would aid in the selection of patients with theappropriate risk-benefit ratio for implantation of an active pump.

Original languageEnglish (US)
Pages (from-to)275-282
Number of pages8
JournalJACC: Heart Failure
Volume3
Issue number4
DOIs
StatePublished - Apr 1 2015

Keywords

  • CO
  • HCM
  • HFpEF
  • HFrEF
  • HTN
  • Heart failure with preserved ejection fraction
  • LA
  • LV
  • LVAD
  • MCS
  • Mechanical circulatory support
  • NYHA
  • PCWP
  • RCM
  • VAD

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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