Left dorsomedial frontal brain damage is associated with insomnia

Michael Koenigs*, Jessica Holliday, Jeffrey Solomon, Jordan Grafman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Insomnia is a common sleep disorder, yet its pathophysiological basis remains poorly understood. Studying a group of 192 patients with focal brain lesions, we show a significant association between insomnia and left dorsomedial prefrontal damage. Our findings are the first to demonstrate a link between insomnia and a discrete locus of brain damage, providing novel insight into the neurobiological mechanisms of sleep maintenance.

Original languageEnglish (US)
Pages (from-to)16041-16043
Number of pages3
JournalJournal of Neuroscience
Issue number47
StatePublished - Nov 24 2010

ASJC Scopus subject areas

  • General Neuroscience


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