TY - JOUR
T1 - Left dorsomedial frontal brain damage is associated with insomnia
AU - Koenigs, Michael
AU - Holliday, Jessica
AU - Solomon, Jeffrey
AU - Grafman, Jordan
PY - 2010/11/24
Y1 - 2010/11/24
N2 - Insomnia is a common sleep disorder, yet its pathophysiological basis remains poorly understood. Studying a group of 192 patients with focal brain lesions, we show a significant association between insomnia and left dorsomedial prefrontal damage. Our findings are the first to demonstrate a link between insomnia and a discrete locus of brain damage, providing novel insight into the neurobiological mechanisms of sleep maintenance.
AB - Insomnia is a common sleep disorder, yet its pathophysiological basis remains poorly understood. Studying a group of 192 patients with focal brain lesions, we show a significant association between insomnia and left dorsomedial prefrontal damage. Our findings are the first to demonstrate a link between insomnia and a discrete locus of brain damage, providing novel insight into the neurobiological mechanisms of sleep maintenance.
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U2 - 10.1523/JNEUROSCI.3745-10.2010
DO - 10.1523/JNEUROSCI.3745-10.2010
M3 - Article
C2 - 21106842
AN - SCOPUS:78649408849
SN - 0270-6474
VL - 30
SP - 16041
EP - 16043
JO - Journal of Neuroscience
JF - Journal of Neuroscience
IS - 47
ER -