Left rostrolateral prefrontal cortex lesions reduce suicidal ideation in penetrating traumatic brain injury

Matteo Pardini; Jordan Henry Grafman; Vanessa Raymont; Mario Amore; Gianluca Serafini; Michael Koenigs; Frank Krueger

doi:10.1017/S1092852918001694

Left rostrolateral prefrontal cortex lesions reduce suicidal ideation in penetrating traumatic brain injury

Matteo Pardini, Jordan Henry Grafman^*, Vanessa Raymont, Mario Amore, Gianluca Serafini, Michael Koenigs, Frank Krueger

^*Corresponding author for this work

Physical Medicine and Rehabilitation

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Objectives. The objective of this study is to evaluate the relationship between suicidal ideation (SI), structural brain damage, and cognitive deficits in patients with penetrating traumatic brain injury (pTBI).Methods. Vietnam War veterans (n = 142) with pTBI to the prefrontal cortex (PFC) underwent combination of neuropsychological and psychiatric examinations and non-contrast CT brain scan. Patients were divided into SI positive (SI+) and SI negative (SI-) groups according to the SI item of the Beck Depression Inventory.Results. Lesions to the left rostrolateral PFC (rlPFC) were associated with a lower risk of SI independent of depression and global functioning. Left rlPFC lesion also reduced abstract reasoning skills, which mediated the lesion effects on suicide ideation.Conclusions. The left rlPFC plays a crucial role in SI independently of depression and global functioning.

Original language	English (US)
Pages (from-to)	24-31
Number of pages	8
Journal	CNS spectrums
Volume	25
Issue number	1
DOIs	https://doi.org/10.1017/S1092852918001694
State	Published - Feb 1 2020

Funding

*Address correspondence to: Frank Krueger, PhD, School of Systems Biology, George Mason University, 4400 University Drive, Fairfax, MS 2A1, VA 22030, USA. (Email: [email protected]). For general information regarding the Vietnam Head Injury Study (VHIS) registry please contact: Jordan Grafman, PhD, Cognitive Neuroscience Laboratory, Shirley Ryan AbilityLab, Chicago, IL, USA. (Email: [email protected]) This work was supported by the National Institute of Neurological Disorders and Stroke intramural research program and a project grant from the United Sates Army Medical Research and Material Command administered by the Henry M. Jackson Foundation (Vietnam Head Injury Study Phase III: A 30 Year Post-Injury Follow-Up Study, Grant number DAMD17-01-1-0675). We are grateful to S. Bonifant, B. Cheon, C. Ngo, A. Greathouse, K. Reding, and G. Tasick for their invaluable help with the testing of participants and organization of this study. We thank Sergio Paradiso, MD, for his insights on the possible effects of pTBI on SI.

Keywords

Key Suicidality
cognition
frontal lobe
traumatic brain injury

ASJC Scopus subject areas

Clinical Neurology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1017/S1092852918001694

Cite this

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title = "Left rostrolateral prefrontal cortex lesions reduce suicidal ideation in penetrating traumatic brain injury",

abstract = "Objectives. The objective of this study is to evaluate the relationship between suicidal ideation (SI), structural brain damage, and cognitive deficits in patients with penetrating traumatic brain injury (pTBI).Methods. Vietnam War veterans (n = 142) with pTBI to the prefrontal cortex (PFC) underwent combination of neuropsychological and psychiatric examinations and non-contrast CT brain scan. Patients were divided into SI positive (SI+) and SI negative (SI-) groups according to the SI item of the Beck Depression Inventory.Results. Lesions to the left rostrolateral PFC (rlPFC) were associated with a lower risk of SI independent of depression and global functioning. Left rlPFC lesion also reduced abstract reasoning skills, which mediated the lesion effects on suicide ideation.Conclusions. The left rlPFC plays a crucial role in SI independently of depression and global functioning.",

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AU - Raymont, Vanessa

AU - Amore, Mario

AU - Serafini, Gianluca

AU - Koenigs, Michael

AU - Krueger, Frank

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N2 - Objectives. The objective of this study is to evaluate the relationship between suicidal ideation (SI), structural brain damage, and cognitive deficits in patients with penetrating traumatic brain injury (pTBI).Methods. Vietnam War veterans (n = 142) with pTBI to the prefrontal cortex (PFC) underwent combination of neuropsychological and psychiatric examinations and non-contrast CT brain scan. Patients were divided into SI positive (SI+) and SI negative (SI-) groups according to the SI item of the Beck Depression Inventory.Results. Lesions to the left rostrolateral PFC (rlPFC) were associated with a lower risk of SI independent of depression and global functioning. Left rlPFC lesion also reduced abstract reasoning skills, which mediated the lesion effects on suicide ideation.Conclusions. The left rlPFC plays a crucial role in SI independently of depression and global functioning.

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KW - Key Suicidality

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KW - frontal lobe

KW - traumatic brain injury

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Left rostrolateral prefrontal cortex lesions reduce suicidal ideation in penetrating traumatic brain injury

Abstract

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Keywords

ASJC Scopus subject areas

UN SDGs

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