Left rostrolateral prefrontal cortex lesions reduce suicidal ideation in penetrating traumatic brain injury

Matteo Pardini, Jordan Henry Grafman*, Vanessa Raymont, Mario Amore, Gianluca Serafini, Michael Koenigs, Frank Krueger

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Objectives.The objective of this study is to evaluate the relationship between suicidal ideation (SI), structural brain damage, and cognitive deficits in patients with penetrating traumatic brain injury (pTBI).Methods.Vietnam War veterans (n = 142) with pTBI to the prefrontal cortex (PFC) underwent combination of neuropsychological and psychiatric examinations and non-contrast CT brain scan. Patients were divided into SI positive (SI+) and SI negative (SI-) groups according to the SI item of the Beck Depression Inventory.Results.Lesions to the left rostrolateral PFC (rlPFC) were associated with a lower risk of SI independent of depression and global functioning. Left rlPFC lesion also reduced abstract reasoning skills, which mediated the lesion effects on suicide ideation.Conclusions.The left rlPFC plays a crucial role in SI independently of depression and global functioning.

Original languageEnglish (US)
JournalCNS spectrums
DOIs
StatePublished - Jan 1 2019

Fingerprint

Penetrating Head Injuries
Suicidal Ideation
Prefrontal Cortex
Depression
Traumatic Brain Injury
Vietnam
Brain
Veterans
Suicide
Psychiatry
Equipment and Supplies

Keywords

  • Suicidality
  • cognition
  • frontal lobe
  • traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Pardini, Matteo ; Grafman, Jordan Henry ; Raymont, Vanessa ; Amore, Mario ; Serafini, Gianluca ; Koenigs, Michael ; Krueger, Frank. / Left rostrolateral prefrontal cortex lesions reduce suicidal ideation in penetrating traumatic brain injury. In: CNS spectrums. 2019.
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abstract = "Objectives.The objective of this study is to evaluate the relationship between suicidal ideation (SI), structural brain damage, and cognitive deficits in patients with penetrating traumatic brain injury (pTBI).Methods.Vietnam War veterans (n = 142) with pTBI to the prefrontal cortex (PFC) underwent combination of neuropsychological and psychiatric examinations and non-contrast CT brain scan. Patients were divided into SI positive (SI+) and SI negative (SI-) groups according to the SI item of the Beck Depression Inventory.Results.Lesions to the left rostrolateral PFC (rlPFC) were associated with a lower risk of SI independent of depression and global functioning. Left rlPFC lesion also reduced abstract reasoning skills, which mediated the lesion effects on suicide ideation.Conclusions.The left rlPFC plays a crucial role in SI independently of depression and global functioning.",
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Left rostrolateral prefrontal cortex lesions reduce suicidal ideation in penetrating traumatic brain injury. / Pardini, Matteo; Grafman, Jordan Henry; Raymont, Vanessa; Amore, Mario; Serafini, Gianluca; Koenigs, Michael; Krueger, Frank.

In: CNS spectrums, 01.01.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Left rostrolateral prefrontal cortex lesions reduce suicidal ideation in penetrating traumatic brain injury

AU - Pardini, Matteo

AU - Grafman, Jordan Henry

AU - Raymont, Vanessa

AU - Amore, Mario

AU - Serafini, Gianluca

AU - Koenigs, Michael

AU - Krueger, Frank

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Objectives.The objective of this study is to evaluate the relationship between suicidal ideation (SI), structural brain damage, and cognitive deficits in patients with penetrating traumatic brain injury (pTBI).Methods.Vietnam War veterans (n = 142) with pTBI to the prefrontal cortex (PFC) underwent combination of neuropsychological and psychiatric examinations and non-contrast CT brain scan. Patients were divided into SI positive (SI+) and SI negative (SI-) groups according to the SI item of the Beck Depression Inventory.Results.Lesions to the left rostrolateral PFC (rlPFC) were associated with a lower risk of SI independent of depression and global functioning. Left rlPFC lesion also reduced abstract reasoning skills, which mediated the lesion effects on suicide ideation.Conclusions.The left rlPFC plays a crucial role in SI independently of depression and global functioning.

AB - Objectives.The objective of this study is to evaluate the relationship between suicidal ideation (SI), structural brain damage, and cognitive deficits in patients with penetrating traumatic brain injury (pTBI).Methods.Vietnam War veterans (n = 142) with pTBI to the prefrontal cortex (PFC) underwent combination of neuropsychological and psychiatric examinations and non-contrast CT brain scan. Patients were divided into SI positive (SI+) and SI negative (SI-) groups according to the SI item of the Beck Depression Inventory.Results.Lesions to the left rostrolateral PFC (rlPFC) were associated with a lower risk of SI independent of depression and global functioning. Left rlPFC lesion also reduced abstract reasoning skills, which mediated the lesion effects on suicide ideation.Conclusions.The left rlPFC plays a crucial role in SI independently of depression and global functioning.

KW - Suicidality

KW - cognition

KW - frontal lobe

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