Spindle cell lipoma (SCL) is a rare variant of lipoma that has the gross appearance of a lipoma with white or gray gelatinous areas. Only 3 cases have been reported in the parotid area. Most cases are seen in the upper back and neck. Histologically, SCL features a uniform proliferation of spindle cells with single elongated nuclei in a matrix of collagen and mucoid material without "signet-ring" lipoblasts. Immunohistochemically, SCL shows diffuse cytoplasmic positivity for CD34 in the spindle cells. Spindle cell lipoma has histologic similarities to liposarcoma but is distinguished from it by a lack of cellular atypia and an absence of lipoblasts. In addition, liposarcoma is usually deep seated and less circumscribed compared to the superficial, well-circumscribed, and lobulated SCL.
|Original language||English (US)|
|Number of pages||2|
|Journal||Archives of Pathology and Laboratory Medicine|
|State||Published - Jun 2006|
ASJC Scopus subject areas
- Pathology and Forensic Medicine
- Medical Laboratory Technology