Left ventricular apical thrombus and myocardial viability: A dobutamine stress echocardiographic study

David A. Cusick, Robert O Bonow, Farooq A. Chaudhry*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The objective of this article was to determine whether the presence of left ventricular apical thrombus is a marker of nonviable myocardium. Reduced coronary blood flow secondary to atherosclerosis may result in chronic reversible left ventricular wall-motion abnormalities. Severe regional abnormalities also predispose to formation of left ventricular thrombus. The relationship between left ventricular apical thrombus and myocardial viability has not been previously described. Eighty patients with coronary artery disease and chronic left ventricular dysfunction were studied by dobutamine stress echocardiography. Left ventricular apical thrombus was identified using echocardiographic criteria. Wall-motion analysis was performed using a standard 16-segment model and ejection fraction was calculated. As a result, 48 patients (60%) had definite or highly suspicious findings for left ventricular thrombus (group 1), and 32 patients (40%) had no thrombus (group 2). Group I had significantly higher composite (54.0 ± 5.8 vs 43.3 ± 6.4) and apical (6.0 ± 2.7 vs 12.4 ± 3.4) wall-motion scores compared to those in group 2 (P = 0.01). Thirty-two patients (67%) in group I demonstrated no contractile reserve in the apical segments, consistent with lack of viability, versus eight patients (25%) in group 2 (P = 0.0003). The number of viable apical segments per patient was significantly less in group 1 (0.7 ± 1.2) versus group 2 (1.8 ± 1.3) (P = 0.01). Left ventricular apical thrombus is more likely to be present when there is absence of myocardial viability in the corresponding segments.

Original languageEnglish (US)
Pages (from-to)547-554
Number of pages8
JournalEchocardiography
Volume17
Issue number6 I
DOIs
StatePublished - Jan 1 2000

Keywords

  • Dobutamine stress echocardiography
  • Myocardial viability
  • Ventricular thrombus

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Left ventricular apical thrombus and myocardial viability: A dobutamine stress echocardiographic study'. Together they form a unique fingerprint.

Cite this