Left Ventricular Hypertrophy and Cognitive Decline in Old Age

Simin Mahinrad, Annelotte E. Vriend, J. Wouter Jukema, Diana Van Heemst, Naveed Sattar, Gerard Jan Blauw, Peter W. Macfarlane, Elaine N. Clark, Anton J.M. De Craen, Behnam Sabayan*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Background: Patients with advanced heart failure run a greater risk of dementia. Whether early cardiac structural changes also associate with cognitive decline is yet to be determined. Objective: We tested whether left ventricular hypertrophy (LVH) derived from electrocardiogram associates with cognitive decline in older subjects at risk of cardiovascular disease. Methods: We included 4,233 participants (mean age 75.2 years, 47.8% male) from PROSPER (PROspective Study of Pravastatin in the Elderly at Risk). LVH was assessed from baseline electrocardiograms by measuring the Sokolow-Lyon index. Higher levels of Sokolow-Lyon index indicate higher degrees of LVH. Cognitive domains involving selective attention, processing speed, and immediate and delayed memory were measured at baseline and repeated during a mean follow-up of 3.2 years. Results: At baseline, LVH was not associated with worse cognitive function. During follow-up, participants with higher levels of LVH had a steeper decline in cognitive function including in selective attention (p = 0.009), processing speed (p = 0.010), immediate memory (p < 0.001), and delayed memory (p = 0.002). These associations were independent of cardiovascular risk factors, co-morbidities, and medications. Conclusion: LVH assessed by electrocardiogram associates with steeper decline in cognitive function of older subjects independent of cardiovascular risk factors and co-morbidities. This study provides further evidence on the link between subclinical cardiac structural changes and cognitive decline in older subjects.

Original languageEnglish (US)
Pages (from-to)275-283
Number of pages9
JournalJournal of Alzheimer's Disease
Issue number1
StatePublished - 2017
Externally publishedYes


  • Cardiovascular disease
  • cognitive function
  • elderly
  • left ventricular hypertrophy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Psychology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health


Dive into the research topics of 'Left Ventricular Hypertrophy and Cognitive Decline in Old Age'. Together they form a unique fingerprint.

Cite this