Abstract
Background: Cord blood (CB) leptin is positively associated with adiposity at birth, but the association with child adiposity is unclear. Objectives: We hypothesized that CB leptin is positively associated with adiposity in peripubertal children and with childhood leptin. Methods: Leptin was measured in 986 CB and 931 childhood stored samples from a prospective birth cohort. Adiposity measures were collected at birth and mean age 11.5 years. Linear and logistic regression analyses were used to evaluate associations between log-transformed CB leptin and neonatal and childhood adiposity measures as continuous and categorical variables, respectively. Results: CB leptin was positively associated with neonatal and childhood adiposity. Childhood associations were attenuated when adjusted for maternal body mass index (BMI) and glucose, but remained statistically significant for childhood body fat percentage (β = 1.15%, confidence interval [CI] = 0.46–1.84), body fat mass (β = 0.69 kg, 95% CI = 0.16–1.23), sum of skin-folds (β = 1.77 mm, 95% CI = 0.31–3.24), log-transformed child serum leptin (β = 0.13, 95% CI = 0.06–0.20), overweight/obesity (OR = 1.21, 95% CI = 1.03–1.42), obesity (OR = 1.31, 95% CI = 1.04–1.66) and body fat percentage >85th percentile (OR = 1.38, 95% CI = 1.12–1.73). Positive associations between newborn adiposity measures and CB leptin confirmed previous reports. Conclusion: CB leptin is positively associated with neonatal and childhood adiposity and child leptin levels, independent of maternal BMI and maternal hyperglycemia. CB leptin may be a biomarker of future adiposity risk.
| Original language | English (US) |
|---|---|
| Article number | e13087 |
| Journal | Pediatric Obesity |
| Volume | 19 |
| Issue number | 2 |
| DOIs | |
| State | Published - Feb 2024 |
Funding
Ruth L. Kirschstein National Research Service Award T32 DK007169 (Sean DeLacey) and NIH R01DK118403 (Jami L. Josefson). The child biospecimens from the HAPO FUS reported here were supplied by the NIDDK Central Repository. The HAPO FUS was funded by grant 1U01DK094830 from the National Institute of Diabetes and Digestive and Kidney Diseases and the Eunice Kennedy Shrive National Institute of Child Health and Human Development and its Principal Investigator was Boyd Metzger. The HAPO Study was funded by grants R01‐HD‐34242 and R01‐HD‐34243 from the Eunice Kennedy Shrive National Institute of Child Health and Human Development and its Principal Investigator was Boyd Metzger, MD. The HAPO FUS data were collected and managed using REDCap electronic data capture tools hosted at the Northwestern University Feinberg School of Medicine. REDCap is supported at Feinberg School of Medicine by the Northwestern University Clinical and Translational Science Institute. The research reported in this article was supported, in part, by grant UL2TR001422 from the National Center for Advancing Translational Sciences, National Institutes of Health. This work was supported by the Comprehensive Metabolic Core at Northwestern University. The child biospecimens from the HAPO FUS reported here were supplied by the NIDDK Central Repository. The work relied upon previous research from the HAPO and HAPO FUS consortiums. This manuscript was reviewed and approved by investigators of the HAPO FUS and does not necessarily reflect the opinions or views of the NIDDK Central Repository, or the NIDDK.
Keywords
- adiposity
- cord blood
- gestational diabetes mellitus
- leptin
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Health Policy
- Nutrition and Dietetics
- Public Health, Environmental and Occupational Health
