Leptomeningeal metastases: the future is now

Rimas V. Lukas; Jigisha P. Thakkar; Massimo Cristofanilli; Sunandana Chandra; Jeffrey A. Sosman; Jyoti D. Patel; Priya Kumthekar; Roger Stupp; Maciej S. Lesniak

doi:10.1007/s11060-021-03924-2

Leptomeningeal metastases: the future is now

Rimas V. Lukas^*, Jigisha P. Thakkar, Massimo Cristofanilli, Sunandana Chandra, Jeffrey A. Sosman, Jyoti D. Patel, Priya Kumthekar, Roger Stupp, Maciej S. Lesniak

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

9 Scopus citations

Abstract

Leptomeningeal metastases (LM) constitute an involvement of cancer which is associated with marked morbidity and mortality. The contemporary diagnostic and therapeutic management of LM from solid tumors is reviewed. Therapeutic modalities including systemic therapies, cerebrospinal fluid (CSF)-directed therapies, and radiation therapy are discussed. This is to provide context for how the field of LM management may evolve in the near term. The future directions currently undergoing investigation for diagnostic, response assessment, and therapeutic purposes are highlighted. This is done within the context of the pathophysiology of the disease. Specifically the role of CSF circulating tumor cells and cell free circulating tumor DNA in diagnosis and response assement are reviewed. Novel therapeutic approaches across a range of modalities are discussed. Numerous ongoing studies which have the potential to alter the management of LM are referenced.

Original language	English (US)
Pages (from-to)	443-452
Number of pages	10
Journal	Journal of Neuro-Oncology
Volume	156
Issue number	3
DOIs	https://doi.org/10.1007/s11060-021-03924-2
State	Published - Feb 2022

Keywords

CSF
Carcinomatous meningitis
Circulating tumor DNA
Intrathecal therapy
Leptomeningeal metastases

ASJC Scopus subject areas

Clinical Neurology
Neurology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s11060-021-03924-2

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title = "Leptomeningeal metastases: the future is now",

abstract = "Leptomeningeal metastases (LM) constitute an involvement of cancer which is associated with marked morbidity and mortality. The contemporary diagnostic and therapeutic management of LM from solid tumors is reviewed. Therapeutic modalities including systemic therapies, cerebrospinal fluid (CSF)-directed therapies, and radiation therapy are discussed. This is to provide context for how the field of LM management may evolve in the near term. The future directions currently undergoing investigation for diagnostic, response assessment, and therapeutic purposes are highlighted. This is done within the context of the pathophysiology of the disease. Specifically the role of CSF circulating tumor cells and cell free circulating tumor DNA in diagnosis and response assement are reviewed. Novel therapeutic approaches across a range of modalities are discussed. Numerous ongoing studies which have the potential to alter the management of LM are referenced.",

keywords = "CSF, Carcinomatous meningitis, Circulating tumor DNA, Intrathecal therapy, Leptomeningeal metastases",

author = "Lukas, {Rimas V.} and Thakkar, {Jigisha P.} and Massimo Cristofanilli and Sunandana Chandra and Sosman, {Jeffrey A.} and Patel, {Jyoti D.} and Priya Kumthekar and Roger Stupp and Lesniak, {Maciej S.}",

note = "Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",

year = "2022",

month = feb,

doi = "10.1007/s11060-021-03924-2",

language = "English (US)",

volume = "156",

pages = "443--452",

journal = "Journal of Neuro-Oncology",

issn = "0167-594X",

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TY - JOUR

T1 - Leptomeningeal metastases

T2 - the future is now

AU - Lukas, Rimas V.

AU - Thakkar, Jigisha P.

AU - Cristofanilli, Massimo

AU - Chandra, Sunandana

AU - Sosman, Jeffrey A.

AU - Patel, Jyoti D.

AU - Kumthekar, Priya

AU - Stupp, Roger

AU - Lesniak, Maciej S.

PY - 2022/2

Y1 - 2022/2

N2 - Leptomeningeal metastases (LM) constitute an involvement of cancer which is associated with marked morbidity and mortality. The contemporary diagnostic and therapeutic management of LM from solid tumors is reviewed. Therapeutic modalities including systemic therapies, cerebrospinal fluid (CSF)-directed therapies, and radiation therapy are discussed. This is to provide context for how the field of LM management may evolve in the near term. The future directions currently undergoing investigation for diagnostic, response assessment, and therapeutic purposes are highlighted. This is done within the context of the pathophysiology of the disease. Specifically the role of CSF circulating tumor cells and cell free circulating tumor DNA in diagnosis and response assement are reviewed. Novel therapeutic approaches across a range of modalities are discussed. Numerous ongoing studies which have the potential to alter the management of LM are referenced.

AB - Leptomeningeal metastases (LM) constitute an involvement of cancer which is associated with marked morbidity and mortality. The contemporary diagnostic and therapeutic management of LM from solid tumors is reviewed. Therapeutic modalities including systemic therapies, cerebrospinal fluid (CSF)-directed therapies, and radiation therapy are discussed. This is to provide context for how the field of LM management may evolve in the near term. The future directions currently undergoing investigation for diagnostic, response assessment, and therapeutic purposes are highlighted. This is done within the context of the pathophysiology of the disease. Specifically the role of CSF circulating tumor cells and cell free circulating tumor DNA in diagnosis and response assement are reviewed. Novel therapeutic approaches across a range of modalities are discussed. Numerous ongoing studies which have the potential to alter the management of LM are referenced.

KW - CSF

KW - Carcinomatous meningitis

KW - Circulating tumor DNA

KW - Intrathecal therapy

KW - Leptomeningeal metastases

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UR - http://www.scopus.com/inward/citedby.url?scp=85123112394&partnerID=8YFLogxK

U2 - 10.1007/s11060-021-03924-2

DO - 10.1007/s11060-021-03924-2

M3 - Review article

C2 - 35048267

AN - SCOPUS:85123112394

SN - 0167-594X

VL - 156

SP - 443

EP - 452

JO - Journal of Neuro-Oncology

JF - Journal of Neuro-Oncology

IS - 3

ER -

Leptomeningeal metastases: the future is now

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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