Leptomeningeal metastasis from solid tumors

Jigisha P. Thakkar; Priya Kumthekar; Karan S. Dixit; Roger Stupp; Rimas V. Lukas

doi:10.1016/j.jns.2020.116706

Leptomeningeal metastasis from solid tumors

Jigisha P. Thakkar, Priya Kumthekar, Karan S. Dixit, Roger Stupp, Rimas V. Lukas^*

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

55 Scopus citations

Abstract

Central nervous system (CNS) metastasis from systemic cancers can involve the brain parenchyma, leptomeninges (pia, subarachnoid space and arachnoid mater), and dura. Leptomeningeal metastases (LM), also known by different terms including neoplastic meningitis and carcinomatous meningitis, occur in both solid tumors and hematologic malignancies. This review will focus exclusively on LM arising from solid tumors with a goal of providing the reader an understanding of the epidemiology, pathophysiology, clinical presentation, prognostication, current management and future directions.

Original language	English (US)
Article number	116706
Journal	Journal of the Neurological Sciences
Volume	411
DOIs	https://doi.org/10.1016/j.jns.2020.116706
State	Published - Apr 15 2020

Keywords

Carcinomatous meningitis
Central nervous system metastases
Cerebrospinal fluid
Intrathecal chemotherapy
Leptomeningeal metastases

ASJC Scopus subject areas

Clinical Neurology
Neurology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jns.2020.116706

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@article{07739d2b879e4ec18083bbe1a3f54a19,

title = "Leptomeningeal metastasis from solid tumors",

abstract = "Central nervous system (CNS) metastasis from systemic cancers can involve the brain parenchyma, leptomeninges (pia, subarachnoid space and arachnoid mater), and dura. Leptomeningeal metastases (LM), also known by different terms including neoplastic meningitis and carcinomatous meningitis, occur in both solid tumors and hematologic malignancies. This review will focus exclusively on LM arising from solid tumors with a goal of providing the reader an understanding of the epidemiology, pathophysiology, clinical presentation, prognostication, current management and future directions.",

keywords = "Carcinomatous meningitis, Central nervous system metastases, Cerebrospinal fluid, Intrathecal chemotherapy, Leptomeningeal metastases",

author = "Thakkar, {Jigisha P.} and Priya Kumthekar and Dixit, {Karan S.} and Roger Stupp and Lukas, {Rimas V.}",

note = "Publisher Copyright: {\textcopyright} 2020 Elsevier B.V.",

year = "2020",

month = apr,

day = "15",

doi = "10.1016/j.jns.2020.116706",

language = "English (US)",

volume = "411",

journal = "Journal of the Neurological Sciences",

issn = "0022-510X",

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TY - JOUR

T1 - Leptomeningeal metastasis from solid tumors

AU - Thakkar, Jigisha P.

AU - Kumthekar, Priya

AU - Dixit, Karan S.

AU - Stupp, Roger

AU - Lukas, Rimas V.

PY - 2020/4/15

Y1 - 2020/4/15

N2 - Central nervous system (CNS) metastasis from systemic cancers can involve the brain parenchyma, leptomeninges (pia, subarachnoid space and arachnoid mater), and dura. Leptomeningeal metastases (LM), also known by different terms including neoplastic meningitis and carcinomatous meningitis, occur in both solid tumors and hematologic malignancies. This review will focus exclusively on LM arising from solid tumors with a goal of providing the reader an understanding of the epidemiology, pathophysiology, clinical presentation, prognostication, current management and future directions.

AB - Central nervous system (CNS) metastasis from systemic cancers can involve the brain parenchyma, leptomeninges (pia, subarachnoid space and arachnoid mater), and dura. Leptomeningeal metastases (LM), also known by different terms including neoplastic meningitis and carcinomatous meningitis, occur in both solid tumors and hematologic malignancies. This review will focus exclusively on LM arising from solid tumors with a goal of providing the reader an understanding of the epidemiology, pathophysiology, clinical presentation, prognostication, current management and future directions.

KW - Carcinomatous meningitis

KW - Central nervous system metastases

KW - Cerebrospinal fluid

KW - Intrathecal chemotherapy

KW - Leptomeningeal metastases

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U2 - 10.1016/j.jns.2020.116706

DO - 10.1016/j.jns.2020.116706

M3 - Review article

C2 - 32007755

AN - SCOPUS:85078681195

SN - 0022-510X

VL - 411

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

M1 - 116706

ER -

Leptomeningeal metastasis from solid tumors

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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