Leptomeningeal metastasis from solid tumors

Jigisha P. Thakkar, Priya Kumthekar, Karan S. Dixit, Roger Stupp, Rimas V. Lukas*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Central nervous system (CNS) metastasis from systemic cancers can involve the brain parenchyma, leptomeninges (pia, subarachnoid space and arachnoid mater), and dura. Leptomeningeal metastases (LM), also known by different terms including neoplastic meningitis and carcinomatous meningitis, occur in both solid tumors and hematologic malignancies. This review will focus exclusively on LM arising from solid tumors with a goal of providing the reader an understanding of the epidemiology, pathophysiology, clinical presentation, prognostication, current management and future directions.

Original languageEnglish (US)
Article number116706
JournalJournal of the Neurological Sciences
StatePublished - Apr 15 2020


  • Carcinomatous meningitis
  • Central nervous system metastases
  • Cerebrospinal fluid
  • Intrathecal chemotherapy
  • Leptomeningeal metastases

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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