Lesions of glucose-responsive neurons impair synchronizing effects of calorie restriction in mice

Etienne Challet*, Daniel J. Bernard, Fred W. Turek

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Calorie restriction can induce phase-advances of daily rhythms in rodents exposed to light-dark cycles. To test whether glucose-responsive neurons are involved in the synchronizing effects of calorie restriction, C57BL/6J mice were injected with gold-thioglucose (GTG; 0.6 g/kg) which damages glucose-responsive neurons, primarily located in the ventromedial hypothalamus. From the day of injection, GTG-treated and control mice received a hypocaloric diet (66% of ad libitum food intake) 2 h after lights on. When mice were transferred to constant darkness after 4 weeks and fed ad libitum, the onset of circadian rhythm of locomotor activity was phase- advanced by 1 h in control but not in GTG-treated mice. Therefore, glucose- responsive neurons in the ventromedial hypothalamus may play a role in the synchronizing effects of calorie restriction on circadian rhythmicity.

Original languageEnglish (US)
Pages (from-to)244-250
Number of pages7
JournalBrain research
Volume801
Issue number1-2
DOIs
StatePublished - Aug 10 1998

Keywords

  • Circadian rhythm
  • Food restriction
  • Gold thioglucose
  • Suprachiasmatic nucleus
  • Ventromedial hypothalamus

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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