Lesions of the Mid-Spinal trigeminal complex are effective in producing perioral thermal hypoalgesia

Judy F. Pickoff-Matuk*, J. Peter Rosenfeld, James G. Broton

*Corresponding author for this work

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

The hypoalgesic effects of lesions in the rat spinal trigeminal complex at the levels of subnucleus interpolaris and caudal subnucleus oralis were investigated. Lesions of the trigeminal tract, nucleus, or adjacent reticular formation resulted in significant elevations in escape latencies to noxious thermal stimulation of the ipsilateral perioral area. The nuclear lesions were significantly more effective in producing latency elevations than were the reticular formation lesions. Behavioral and anatomical evidence is presented suggesting that the mid-spinal trigeminal complex, including the ascending trigeminal intranuclear pathways, participate in perioral thermal nociception.

Original languageEnglish (US)
Pages (from-to)291-298
Number of pages8
JournalBrain research
Volume382
Issue number2
DOIs
StatePublished - Sep 24 1986

Keywords

  • hypoalgesia
  • intranuclear projection
  • lesion
  • orofacial pain
  • rat
  • spinal trigeminal complex

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

Fingerprint Dive into the research topics of 'Lesions of the Mid-Spinal trigeminal complex are effective in producing perioral thermal hypoalgesia'. Together they form a unique fingerprint.

  • Cite this