Let-7 repression leads to HMGA2 overexpression in uterine leiomyosarcoma

Guizhi Shi, Mary Ann Perle, Khush Mittal, Hua Chen, Xuanyi Zou, Masashi Narita, Eva Hernando, Peng Lee, Jian Jun Wei*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Overexpression of HMGA2 is common in uterine leiomyomas (ULM). The expression of HMGA2 in its malignant counterpart - uterine leiomyosarcomas (ULMS) remains undetermined. Recently it has been shown that repression of HMGA2 by microRNA let-7s is a critical molecular regulatory mechanism associated with tumour growth in many tumours and cell types, including leiomyomas. To test whether HMGA2 and let-7s play a role in ULMS, we examined the levels of endogenous HMGA2 and let-7 expression and found a significant correlation between these two molecules in a case-matched cohort of human ULMS. We found that overexpression of HMGA2 and let-7-mediated HMGA2 repression is a relevant molecular alteration in ULMS. Disrupting the control of HMGA2 and let-7 pairs promotes ULMS cell growth in vitro.

Original languageEnglish (US)
Pages (from-to)3898-3905
Number of pages8
JournalJournal of Cellular and Molecular Medicine
Volume13
Issue number9 B
DOIs
StatePublished - Sep 2009

ASJC Scopus subject areas

  • Molecular Medicine
  • Cell Biology

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