Leucine-Rich Repeat Kinase 2 Regulates the Progression of Neuropathology Induced by Parkinson's-Disease-Related Mutant α-synuclein

Xian Lin, Loukia Parisiadou, Xing Long Gu, Lizhen Wang, Hoon Shim, Lixin Sun, Chengsong Xie, Cai Xia Long, Wan Jou Yang, Jinhui Ding, Zsu Zsu Chen, Paul E. Gallant, Jung Hwa Tao-Cheng, Gay Rudow, Juan C. Troncoso, Zhihua Liu, Zheng Li, Huaibin Cai*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

348 Scopus citations

Abstract

Mutations in α-synuclein and Leucine-rich repeat kinase 2 (LRRK2) are linked to autosomal dominant forms of Parkinson's disease (PD). However, little is known about any potential pathophysiological interplay between these two PD-related genes. Here we show in transgenic mice that although overexpression of LRRK2 alone did not cause neurodegeneration, the presence of excess LRRK2 greatly accelerated the progression of neuropathological abnormalities developed in PD-related A53T α-synuclein transgenic mice. Moreover, we found that LRRK2 promoted the abnormal aggregation and somatic accumulation of α-synuclein in A53T mice, which likely resulted from the impairment of microtubule dynamics, Golgi organization, and the ubiquitin-proteasome pathway. Conversely, genetic ablation of LRRK2 preserved the Golgi structure and suppressed the aggregation and somatic accumulation of α-synuclein, and thereby delayed the progression of neuropathology in A53T mice. These findings demonstrate that overexpression of LRRK2 enhances α-synuclein-mediated cytotoxicity and suggest inhibition of LRRK2 expression as a potential therapeutic option for ameliorating α-synuclein-induced neurodegeneration.

Original languageEnglish (US)
Pages (from-to)807-827
Number of pages21
JournalNeuron
Volume64
Issue number6
DOIs
StatePublished - Dec 24 2009

Keywords

  • HUMDISEASE
  • MOLNEURO
  • SYSNEURO

ASJC Scopus subject areas

  • Neuroscience(all)

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