| Original language | English (US) |
|---|---|
| Title of host publication | Emery and Rimoin's Principles and Practice of Medical Genetics |
| Publisher | Elsevier Ltd |
| Pages | 1-44 |
| Number of pages | 44 |
| ISBN (Print) | 9780123838346 |
| DOIs | |
| State | Published - 2013 |
Funding
Leukemias, Lymphomas, and Other Related Disorders Cytogenetic Analysis. Biographies Dr Janet D Rowley is Blum-Riese Distinguished Service Professor of Medicine, Molecular Genetics and Cell Biology, and Human Genetics, Pritzker School of Medicine, University of Chicago. She earned a Bachelor of Philosophy degree (1944), a Bachelor of Science degree (1946) and a Doctor of Medicine degree (1948) from the University of Chicago. A faculty member at the University of Chicago since 1962, Dr Rowley is internationally renowned for her studies of chromosome abnormalities in human leukemia and lymphoma. In 1972, she discovered the first consistent chromosome translocation in any human cancer, the t(8;21) in AML. In a landmark paper in 1973, Dr Rowley described the t(9;22) in CML. Subsequently, she identified more than a dozen different recurring translocations in children and adults with leukemia and lymphoma. Her discoveries have resulted in more accurate diagnostic techniques and the development of effective treatment protocols targeted to particular genetic abnormalities, such as Imatinib for CML. Dr Rowley is a member of the National Academy of Sciences, the Institute of Medicine, the American Philosophical Society, and the American Academy of Arts and Sciences. She was awarded the 2011 Ernest Beutler Lecture and Prize from the American Society of Hematology, the Seventh Annual AACR Award for Lifetime Achievement in Cancer Research in 2010, the 2009 Presidential Medal of Freedom, the 1998 Albert Lasker Clinical Research Award, the 1998 National Medal of Science, and the 1989 Charles S. Mott Prize from General Motors Cancer Research Foundation. Dr Yanming Zhang attended a medical school in China in the early 1980s, and received his MD degree in 1994 in Germany. He did postdoctoral research training in cytogenetics in non-Hodgkin lymphoma in Kiel, Germany from 1995 to 1998, and continued on characterizing genomic breakpoints and the mechanisms of chromosome translocations in AML under Dr Janet D Rowley’s guiding at the University of Chicago between 1999 and 2002. Later Dr Zhang finished a 2-year clinical cytogenetics fellowship training that was accredited by the American Board of Medical Genetics, and became a board certified clinical cytogeneticist. From 2005 to 2010, he was Assistant Professor of Medicine, and served as Assistant and Associate Director with Dr Michelle M Le Beau as Director in the Cancer Cytogenetics Laboratory at the University of Chicago. Since 2011, Dr Zhang is Associate Professor of Pathology at Northwestern University, Medical Director of newly established Cytogenetics Laboratory at Northwestern Memorial Hospital, and a member of R. Lurie Comprehensive Cancer Research Center at Northwestern University. Dr Zhang’s research interests are to clarify the mechanisms of recurring chromosome translocations in leukemia and lymphoma and to study genomic imbalances in cancer using genomic microarrays and other molecular techniques.
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology