Leukocyte adhesion deficiency: Recurrent childhood skin infections

Amy S. Paller*, Vandana Nanda, Christa Spates, Maurice O'Gorman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Leukocyte adhesion deficiency is a rare autosomal recessive disorder caused by the absent or severely reduced cell surface expression of a subfamily of leukocyte integrin molecular (β2 leukocyte integrins, CDl 1a/CD 18, CDl 1b/CD18, CD11c/CD18). These molecules are required for the normal processes of leukocyte adherence and chemotaxis. Patients often die during the first years of life of a severe bacterial or fungal infection. We describe a 13-yearold boy with leukocyte adhesion deficiency who had intermittent cutaneous infections that were recalcitrant to treatment. Except for periodontitis, he had no other clinical problems. The diagnosis of leukocyte adhesion deficiency should be considered in patients with recurrent cutaneous infections that do not respond well to therapy, even in the absence of more serious manifestations. Evaluation should include flow cytometry studies to detect surface expression of the β2 leukocyte integrins on both, resting and activated polymorphonuclear leukocytes. (J Am Acad Dermatol 1994;31:36-9.)

Original languageEnglish (US)
Pages (from-to)316-319
Number of pages4
JournalJournal of the American Academy of Dermatology
Issue number2
StatePublished - Jan 1 1994

ASJC Scopus subject areas

  • Dermatology

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