TY - JOUR
T1 - Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response
AU - Muller, William A.
N1 - Funding Information:
I am supported by grants HL46849 and HL64774 from the National Institutes of Health. I wish to thank those scientists named in the legend to Table 1 for helping to formulate a new nomenclature for the JAM family of adhesion molecules.
PY - 2003/6/1
Y1 - 2003/6/1
N2 - Both the innate and adaptive immune responses are dependent on the migration of leukocytes across endothelial cells. The process of diapedesis, in which the leukocyte crawls between tightly apposed endothelial cells, is a unique and complex process. Several molecules concentrated at the junctions of endothelial cells, originally described as having a role in holding the endothelial monolayer together, have also been shown to have a role in the emigration of leukocytes. Several mechanisms have been proposed for 'loosening' the junctions between endothelial cells to enable leukocyte passage. These leukocyte-endothelial-cell adhesion molecules are probably involved in regulating the signaling as well as the adhesion events of diapedesis. In addition, this Review introduces a new and unified nomenclature for the junctional adhesion molecule (JAM) family.
AB - Both the innate and adaptive immune responses are dependent on the migration of leukocytes across endothelial cells. The process of diapedesis, in which the leukocyte crawls between tightly apposed endothelial cells, is a unique and complex process. Several molecules concentrated at the junctions of endothelial cells, originally described as having a role in holding the endothelial monolayer together, have also been shown to have a role in the emigration of leukocytes. Several mechanisms have been proposed for 'loosening' the junctions between endothelial cells to enable leukocyte passage. These leukocyte-endothelial-cell adhesion molecules are probably involved in regulating the signaling as well as the adhesion events of diapedesis. In addition, this Review introduces a new and unified nomenclature for the junctional adhesion molecule (JAM) family.
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U2 - 10.1016/S1471-4906(03)00117-0
DO - 10.1016/S1471-4906(03)00117-0
M3 - Review article
C2 - 12810109
AN - SCOPUS:0038180539
SN - 1471-4906
VL - 24
SP - 326
EP - 333
JO - Trends in Immunology
JF - Trends in Immunology
IS - 6
ER -
