Leukocyte transendothelial migration: A junctional affair

Francis W. Luscinskas*, Shuo Ma, Asma Nusrat, Charles A. Parkos, Sunil K. Shaw

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

95 Scopus citations


A critical function of the inflammatory response is delivery of leukocytes to a site of injury, immune reaction or infection. Considerable information is available concerning the molecular mechanisms that capture flowing leukocytes and initiate their stable arrest on the lumenal surface of the blood vessel wall. In comparison, much less is known about the subsequent step(s) in migration of circulating blood leukocytes across endothelial cell-to-cell lateral borders to underlying tissues. This article will focus on the endothelial-dependent processes that coordinate transmigrations in peripheral vasculature dining the inflammatory response.

Original languageEnglish (US)
Pages (from-to)105-113
Number of pages9
JournalSeminars in Immunology
Issue number2
StatePublished - 2002


  • Cell-cell adhesion
  • Endothelium
  • Inflammation
  • Leukocytes
  • Transmigration

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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