Leukocytes and the natural history of deep vein thrombosis: Current concepts and future directions

Prakash Saha, Julia Humphries, Bijan Modarai, Katherine Mattock, Matthew Waltham, Colin E. Evans, Anwar Ahmad, Ashish S. Patel, Sobath Premaratne, Oliver T.A. Lyons, Alberto Smith*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

113 Scopus citations

Abstract

Observational studies have shown that inflammatory cells accumulate within the thrombus and surrounding vein wall during the natural history of venous thrombosis. More recent studies have begun to unravel the mechanisms that regulate this interaction and have confirmed that thrombosis and inflammation are intimately linked. This review outlines our current knowledge of the complex relationship between inflammatory cell activity and venous thrombosis and highlights new areas of research in this field. A better understanding of this relationship could lead to the development of novel therapeutic targets that inhibit thrombus formation or promote its resolution.

Original languageEnglish (US)
Pages (from-to)506-512
Number of pages7
JournalArteriosclerosis, thrombosis, and vascular biology
Volume31
Issue number3
DOIs
StatePublished - Mar 2011

Keywords

  • immune system
  • leukocytes
  • thrombus resolution
  • vascular biology
  • venous thrombosis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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