TY - JOUR
T1 - Levamisole in Insulin-Dependent Diabetes Mellitus
AU - Cobb, W. E.
AU - Molitch, M.
AU - Reichlin, S.
PY - 1980/10/30
Y1 - 1980/10/30
N2 - To the Editor: If the hypothesis that human insulin-dependent diabetes mellitus (IDDM) may, in some instances, be an autoimmune disorder is correct, 1 it is reasonable to assume that suppression of the immune response should have a favorable effect on the course of the disorder in some patients. To test this hypothesis we recently studied the effect of levamisole (an agent used successfully in other autoimmune disorders, including rheumatoid arthritis2) on islet-cell function in three young adults with IDDM of three months' duration or less. Levamisole, at the doses used in this study, has been thought to be a stimulator.
AB - To the Editor: If the hypothesis that human insulin-dependent diabetes mellitus (IDDM) may, in some instances, be an autoimmune disorder is correct, 1 it is reasonable to assume that suppression of the immune response should have a favorable effect on the course of the disorder in some patients. To test this hypothesis we recently studied the effect of levamisole (an agent used successfully in other autoimmune disorders, including rheumatoid arthritis2) on islet-cell function in three young adults with IDDM of three months' duration or less. Levamisole, at the doses used in this study, has been thought to be a stimulator.
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U2 - 10.1056/NEJM198010303031819
DO - 10.1056/NEJM198010303031819
M3 - Letter
C2 - 6999346
AN - SCOPUS:0019336218
SN - 0028-4793
VL - 303
SP - 1065
EP - 1066
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 18
ER -
