Levels of amoxicillin and ampicillin in human serum and interstitial fluid

J. S. Tan, T. Bannister, J. P. Phair

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Levels of ampicillin and amoxicillin in sera and skin window fluid of 22 volunteers were studied. Higher levels of amoxicillin than of ampicillin were attained. Approximately 20% of both antibiotics circulated in a protein bound form, and the ratio of the concentration in skin window fluid to that in serum were comparable. This finding confirms the authors' studies of penicillins and cephalosporins, in which an inverse relationship between protein binding and diffusion of these antibiotics into the skin window fluid was demonstrated.

Original languageEnglish (US)
Pages (from-to)146-148
Number of pages3
JournalJournal of Infectious Diseases
Volume129
Issue number6 sup.
StatePublished - Dec 1 1974

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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