Leveraging Isothermal Titration Calorimetry to Obtain Thermodynamic Insights into the Binding Behavior and Formation of Metal-Organic Frameworks

Fanrui Sha, Tzu Yi Tai, Madeleine A. Gaidimas, Florencia A. Son, Omar K. Farha*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Isothermal titration calorimetry (ITC) is a technique which directly measures the thermodynamic parameters of binding events. Although historically it has been used to investigate interactions in biological macromolecules and the kinetics of enzyme-catalyzed reactions, ITC has also been demonstrated to provide relevant thermodynamic information about interactions in synthetic systems, such as those in metal-organic frameworks (MOFs). MOFs are a family of crystalline porous materials that have been widely studied as supports for molecules ranging from gases to biomolecules through physisorption and chemisorption. Herein, we offer a perspective on the current applications of ITC in MOFs, including the mechanism of small molecule adsorption and the formation of MOF-based composite materials through noncovalent interactions. Experimental considerations specific to running ITC experiments in MOF systems are reviewed on the basis of existing reports. We conclude by discussing underexplored, but promising, MOF-related research directions which could be elucidated by ITC.

Original languageEnglish (US)
Pages (from-to)6771-6779
Number of pages9
JournalLangmuir
Volume38
Issue number22
DOIs
StatePublished - Jun 7 2022

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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