Leveraging self-assembled nanobiomaterials for improved cancer immunotherapy

Michael P. Vincent, Justin O. Navidzadeh, Sharan Bobbala, Evan A. Scott*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations

Abstract

Nanomaterials and targeted drug delivery vehicles improve the therapeutic index of drugs and permit greater control over their pharmacokinetics, biodistribution, and bioavailability. Here, nanotechnologies applied to cancer immunotherapy are discussed with a focus on current and next generation self-assembling drug delivery systems composed of lipids and/or polymers. Topics covered include the fundamental design, suitability, and inherent properties of nanomaterials that induce anti-tumor immune responses and support anti-cancer vaccination. Established active and passive targeting strategies as well as newer “indirect” methods are presented together with insights into how nanocarrier structure and surface chemistry can be leveraged for controlled delivery to the tumor microenvironment while minimizing off-target effects.

Original languageEnglish (US)
Pages (from-to)255-276
Number of pages22
JournalCancer Cell
Volume40
Issue number3
DOIs
StatePublished - Mar 14 2022

Keywords

  • cancer
  • drug delivery
  • nanomaterial
  • targeting
  • tumor microenvironment
  • vaccine

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

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