Levodopa peak response time reflects severity of dopamine neuron loss in parkinson’s disease

Y. H. Sohn; L. Verhagen Metman; D. Bravi; I. Linfante; A. Aotsuka; M. M. Mouradian; Thomas N. Chase

doi:10.1212/wnl.44.4.755

Levodopa peak response time reflects severity of dopamine neuron loss in parkinson’s disease

Y. H. Sohn, L. Verhagen Metman, D. Bravi, I. Linfante, A. Aotsuka, M. M. Mouradian, Thomas N. Chase^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

We measured the time to peak antiparkinson response following injection of levodopa or apomorphine in 57 patients with Parkinson’s disease. The peak response time for levodopa fell from 53 ± 6.5 minutes in patients at Hoehn and Yahr stage I-II, and 28 ± 4.8 minutes in those at stage IV (p < 0.0005). There was a significant correlation between levodopa peak response time and symptom duration (r = 0.65; p < 0.0001), but there was no relation between apomorphine peak response time and measures of disease severity. Peak response time to levodopa appears to reflect predominantly the status of compensatory presynaptic dopaminergic mechanisms and thus may provide an index to the degree of dopamine neuron degeneration in parkinsonian patients.

Original language	English (US)
Pages (from-to)	755-757
Number of pages	3
Journal	Neurology
Volume	44
Issue number	4
DOIs	https://doi.org/10.1212/wnl.44.4.755
State	Published - Apr 1994

ASJC Scopus subject areas

Clinical Neurology

Access to Document

10.1212/wnl.44.4.755

Cite this

@article{df1d7289477a4763a4625c89969216fe,

title = "Levodopa peak response time reflects severity of dopamine neuron loss in parkinson{\textquoteright}s disease",

abstract = "We measured the time to peak antiparkinson response following injection of levodopa or apomorphine in 57 patients with Parkinson{\textquoteright}s disease. The peak response time for levodopa fell from 53 ± 6.5 minutes in patients at Hoehn and Yahr stage I-II, and 28 ± 4.8 minutes in those at stage IV (p < 0.0005). There was a significant correlation between levodopa peak response time and symptom duration (r = 0.65; p < 0.0001), but there was no relation between apomorphine peak response time and measures of disease severity. Peak response time to levodopa appears to reflect predominantly the status of compensatory presynaptic dopaminergic mechanisms and thus may provide an index to the degree of dopamine neuron degeneration in parkinsonian patients.",

author = "Sohn, {Y. H.} and Metman, {L. Verhagen} and D. Bravi and I. Linfante and A. Aotsuka and Mouradian, {M. M.} and Chase, {Thomas N.}",

year = "1994",

month = apr,

doi = "10.1212/wnl.44.4.755",

language = "English (US)",

volume = "44",

pages = "755--757",

journal = "Neurology",

issn = "0028-3878",

publisher = "Lippincott Williams and Wilkins",

number = "4",

}

TY - JOUR

T1 - Levodopa peak response time reflects severity of dopamine neuron loss in parkinson’s disease

AU - Sohn, Y. H.

AU - Metman, L. Verhagen

AU - Bravi, D.

AU - Linfante, I.

AU - Aotsuka, A.

AU - Mouradian, M. M.

AU - Chase, Thomas N.

PY - 1994/4

Y1 - 1994/4

N2 - We measured the time to peak antiparkinson response following injection of levodopa or apomorphine in 57 patients with Parkinson’s disease. The peak response time for levodopa fell from 53 ± 6.5 minutes in patients at Hoehn and Yahr stage I-II, and 28 ± 4.8 minutes in those at stage IV (p < 0.0005). There was a significant correlation between levodopa peak response time and symptom duration (r = 0.65; p < 0.0001), but there was no relation between apomorphine peak response time and measures of disease severity. Peak response time to levodopa appears to reflect predominantly the status of compensatory presynaptic dopaminergic mechanisms and thus may provide an index to the degree of dopamine neuron degeneration in parkinsonian patients.

AB - We measured the time to peak antiparkinson response following injection of levodopa or apomorphine in 57 patients with Parkinson’s disease. The peak response time for levodopa fell from 53 ± 6.5 minutes in patients at Hoehn and Yahr stage I-II, and 28 ± 4.8 minutes in those at stage IV (p < 0.0005). There was a significant correlation between levodopa peak response time and symptom duration (r = 0.65; p < 0.0001), but there was no relation between apomorphine peak response time and measures of disease severity. Peak response time to levodopa appears to reflect predominantly the status of compensatory presynaptic dopaminergic mechanisms and thus may provide an index to the degree of dopamine neuron degeneration in parkinsonian patients.

UR - http://www.scopus.com/inward/record.url?scp=23444448248&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=23444448248&partnerID=8YFLogxK

U2 - 10.1212/wnl.44.4.755

DO - 10.1212/wnl.44.4.755

M3 - Article

C2 - 8164839

AN - SCOPUS:23444448248

SN - 0028-3878

VL - 44

SP - 755

EP - 757

JO - Neurology

JF - Neurology

IS - 4

ER -

Levodopa peak response time reflects severity of dopamine neuron loss in parkinson’s disease

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this