Abstract
A great team: Cyclopentanes with four contiguous stereogenic centers were assembled with excellent diastereo- and enantioselectivity from simple β,γ-unsaturated α-ketoesters and enals in a reaction catalyzed by an N-heterocyclic carbene (NHC) and mediated by a titanium(IV) Lewis acid (see scheme). The presence of a Lewis acid was essential for the desired transformation to occur.
Original language | English (US) |
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Pages (from-to) | 1678-1682 |
Number of pages | 5 |
Journal | Angewandte Chemie - International Edition |
Volume | 50 |
Issue number | 7 |
DOIs | |
State | Published - Feb 11 2011 |
Keywords
- Lewis acids
- N-heterocyclic carbenes
- asymmetric catalysis
- asymmetric synthesis
- homoenolates
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)