LFA-1 membrane molecule in the regulation of homotypic adhesions of human B lymphocytes

S. J. Mentzer, S. H. Gromkowski, A. M. Krensky, S. J. Burakoff, E. Martz

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

We report here that MAb to human LFA-1 inhibit spontaneous homotypic adhesions of human B lymphocytes. This is, to our knowledge, the first report of a MAb that inhibits human homotypic intercellular adhesions for any cell type. LFA-1 has previously been recognized as a molecule capable of regulating specific immunologic adhesions between T lymphocytes and antigen-bearing target cells. The present findings show that the role of LFA-1 is not limited to adhesions initiated by specific immunologic recognition. The results indicate that the LFA-1 molecule is capable of regulating lymphocyte adhesions, possibly because it is a direct participant in adhesion formation.

Original languageEnglish (US)
Pages (from-to)9-11
Number of pages3
JournalJournal of Immunology
Volume135
Issue number1
StatePublished - 1985

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Fingerprint

Dive into the research topics of 'LFA-1 membrane molecule in the regulation of homotypic adhesions of human B lymphocytes'. Together they form a unique fingerprint.

Cite this