Licensed to elongate: A molecular mechanism for MLL-based leukaemogenesis

Man Mohan, Chengqi Lin, Erin Guest, Ali Shilatifard*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

127 Scopus citations

Abstract

The RNA polymerase II (Pol II) elongation factor (ELL) was the first translocation partner of mixed lineage leukaemia (MLL) for which a biochemical function was determined. It was therefore proposed that the regulation of the elongation stage of transcription could be fundamental to MLL-based leukaemogenesis. Recent studies have identified ELL complexed with several of the translocation partners of MLL in a transcriptional super elongation complex (SEC). These studies provide evidence for the importance of the regulation of Pol II elongation in disease pathogenesis and suggest that MLL chimaeras function by licensing Pol II transcription elongation without the appropriate checkpoints.

Original languageEnglish (US)
Pages (from-to)721-728
Number of pages8
JournalNature Reviews Cancer
Volume10
Issue number10
DOIs
StatePublished - Oct 1 2010

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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