Lifestyle Interventions Limit Gestational Weight Gain in Women with Overweight or Obesity

LIFE-Moms Prospective Meta-Analysis

the LIFE-Moms Research Group

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Objective: This study aimed to evaluate the effects of varied lifestyle intervention programs designed to ameliorate excess gestational weight gain (GWG) in pregnant women with overweight or obesity compared with standard care, including effects on pregnancy outcomes. Methods: Seven clinical centers conducted separate randomized clinical trials to test different lifestyle intervention strategies to modify GWG in diverse populations. Eligibility criteria, specific outcome measures, and assessment procedures were standardized across trials. The results of the separate trials were combined using an individual-participant data meta-analysis. Results: For the 1,150 women randomized, the percent with excess GWG per week was significantly lower in the intervention group compared with the standard care group (61.8% vs. 75.0%; odds ratio [95% CI]: 0.52 [0.40 to 0.67]). Total GWG from enrollment to 36 weeks' gestation was also lower in the intervention group (8.1 ± 5.2 vs. 9.7 ± 5.4 kg; mean difference: −1.59 kg [95% CI:−2.18 to −0.99 kg]). The results from the individual trials were similar. The intervention and standard care groups did not differ in preeclampsia, gestational diabetes, cesarean delivery, or birth weight. Conclusions: Behavioral lifestyle interventions focusing primarily on diet and physical activity among women with overweight and obesity resulted in a significantly lower proportion of women with excess GWG. This modest beneficial effect was consistent across diverse intervention modalities in a large, racially and socioeconomically diverse US population of pregnant women.

Original languageEnglish (US)
Pages (from-to)1396-1404
Number of pages9
JournalObesity
Volume26
Issue number9
DOIs
StatePublished - Sep 1 2018

Fingerprint

Weight Gain
Meta-Analysis
Life Style
Obesity
Pregnant Women
Outcome Assessment (Health Care)
Gestational Diabetes
Pregnancy Outcome
Pre-Eclampsia
Birth Weight
Population
Randomized Controlled Trials
Odds Ratio
Exercise
Diet
Pregnancy

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

@article{397ec85a9a0f4ababac986efd21c63ea,
title = "Lifestyle Interventions Limit Gestational Weight Gain in Women with Overweight or Obesity: LIFE-Moms Prospective Meta-Analysis",
abstract = "Objective: This study aimed to evaluate the effects of varied lifestyle intervention programs designed to ameliorate excess gestational weight gain (GWG) in pregnant women with overweight or obesity compared with standard care, including effects on pregnancy outcomes. Methods: Seven clinical centers conducted separate randomized clinical trials to test different lifestyle intervention strategies to modify GWG in diverse populations. Eligibility criteria, specific outcome measures, and assessment procedures were standardized across trials. The results of the separate trials were combined using an individual-participant data meta-analysis. Results: For the 1,150 women randomized, the percent with excess GWG per week was significantly lower in the intervention group compared with the standard care group (61.8{\%} vs. 75.0{\%}; odds ratio [95{\%} CI]: 0.52 [0.40 to 0.67]). Total GWG from enrollment to 36 weeks' gestation was also lower in the intervention group (8.1 ± 5.2 vs. 9.7 ± 5.4 kg; mean difference: −1.59 kg [95{\%} CI:−2.18 to −0.99 kg]). The results from the individual trials were similar. The intervention and standard care groups did not differ in preeclampsia, gestational diabetes, cesarean delivery, or birth weight. Conclusions: Behavioral lifestyle interventions focusing primarily on diet and physical activity among women with overweight and obesity resulted in a significantly lower proportion of women with excess GWG. This modest beneficial effect was consistent across diverse intervention modalities in a large, racially and socioeconomically diverse US population of pregnant women.",
author = "{the LIFE-Moms Research Group} and Peaceman, {Alan M} and Clifton, {Rebecca G.} and Suzanne Phelan and Dympna Gallagher and Mary Evans and Redman, {Leanne M.} and Knowler, {William C.} and Kaumudi Joshipura and Debra Haire-Joshu and Yanovski, {Susan Z.} and Couch, {Kimberly A.} and Drews, {Kimberly L.} and Franks, {Paul W.} and Samuel Klein and Martin, {Corby K.} and Xavier Pi-Sunyer and Thom, {Elizabeth A.} and {Van Horn}, Linda and Wing, {Rena R.} and Cahill, {Alison G.}",
year = "2018",
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language = "English (US)",
volume = "26",
pages = "1396--1404",
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Lifestyle Interventions Limit Gestational Weight Gain in Women with Overweight or Obesity : LIFE-Moms Prospective Meta-Analysis. / the LIFE-Moms Research Group.

In: Obesity, Vol. 26, No. 9, 01.09.2018, p. 1396-1404.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Lifestyle Interventions Limit Gestational Weight Gain in Women with Overweight or Obesity

T2 - LIFE-Moms Prospective Meta-Analysis

AU - the LIFE-Moms Research Group

AU - Peaceman, Alan M

AU - Clifton, Rebecca G.

AU - Phelan, Suzanne

AU - Gallagher, Dympna

AU - Evans, Mary

AU - Redman, Leanne M.

AU - Knowler, William C.

AU - Joshipura, Kaumudi

AU - Haire-Joshu, Debra

AU - Yanovski, Susan Z.

AU - Couch, Kimberly A.

AU - Drews, Kimberly L.

AU - Franks, Paul W.

AU - Klein, Samuel

AU - Martin, Corby K.

AU - Pi-Sunyer, Xavier

AU - Thom, Elizabeth A.

AU - Van Horn, Linda

AU - Wing, Rena R.

AU - Cahill, Alison G.

PY - 2018/9/1

Y1 - 2018/9/1

N2 - Objective: This study aimed to evaluate the effects of varied lifestyle intervention programs designed to ameliorate excess gestational weight gain (GWG) in pregnant women with overweight or obesity compared with standard care, including effects on pregnancy outcomes. Methods: Seven clinical centers conducted separate randomized clinical trials to test different lifestyle intervention strategies to modify GWG in diverse populations. Eligibility criteria, specific outcome measures, and assessment procedures were standardized across trials. The results of the separate trials were combined using an individual-participant data meta-analysis. Results: For the 1,150 women randomized, the percent with excess GWG per week was significantly lower in the intervention group compared with the standard care group (61.8% vs. 75.0%; odds ratio [95% CI]: 0.52 [0.40 to 0.67]). Total GWG from enrollment to 36 weeks' gestation was also lower in the intervention group (8.1 ± 5.2 vs. 9.7 ± 5.4 kg; mean difference: −1.59 kg [95% CI:−2.18 to −0.99 kg]). The results from the individual trials were similar. The intervention and standard care groups did not differ in preeclampsia, gestational diabetes, cesarean delivery, or birth weight. Conclusions: Behavioral lifestyle interventions focusing primarily on diet and physical activity among women with overweight and obesity resulted in a significantly lower proportion of women with excess GWG. This modest beneficial effect was consistent across diverse intervention modalities in a large, racially and socioeconomically diverse US population of pregnant women.

AB - Objective: This study aimed to evaluate the effects of varied lifestyle intervention programs designed to ameliorate excess gestational weight gain (GWG) in pregnant women with overweight or obesity compared with standard care, including effects on pregnancy outcomes. Methods: Seven clinical centers conducted separate randomized clinical trials to test different lifestyle intervention strategies to modify GWG in diverse populations. Eligibility criteria, specific outcome measures, and assessment procedures were standardized across trials. The results of the separate trials were combined using an individual-participant data meta-analysis. Results: For the 1,150 women randomized, the percent with excess GWG per week was significantly lower in the intervention group compared with the standard care group (61.8% vs. 75.0%; odds ratio [95% CI]: 0.52 [0.40 to 0.67]). Total GWG from enrollment to 36 weeks' gestation was also lower in the intervention group (8.1 ± 5.2 vs. 9.7 ± 5.4 kg; mean difference: −1.59 kg [95% CI:−2.18 to −0.99 kg]). The results from the individual trials were similar. The intervention and standard care groups did not differ in preeclampsia, gestational diabetes, cesarean delivery, or birth weight. Conclusions: Behavioral lifestyle interventions focusing primarily on diet and physical activity among women with overweight and obesity resulted in a significantly lower proportion of women with excess GWG. This modest beneficial effect was consistent across diverse intervention modalities in a large, racially and socioeconomically diverse US population of pregnant women.

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