Light scattering spectroscopy: A new technique for clinical diagnosis of precancerous and cancerous changes in human epithelial tissues

V. Backman; M. Wallace; L. T. Perelman; J. T. Arendt; R. Gurjar; M. G. Muller; Q. Zhang; G. Zonios; E. Kline; T. McGillican; T. Valdez; J. Van Dam; K. Badizadegan; J. M. Crawford; M. Fitzmaurice; S. Kabani; H. S. Levin; M. Seiler; R. R. Dasari; I. Itzkan; M. S. Feld

Light scattering spectroscopy: A new technique for clinical diagnosis of precancerous and cancerous changes in human epithelial tissues

V. Backman, M. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Muller, Q. Zhang, G. Zonios, E. Kline, T. McGillican, T. Valdez, J. Van Dam, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. ItzkanM. S. Feld^*

^*Corresponding author for this work

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We present a light scattering spectroscopy based technique for detection of precancerous and early cancerous changes in human epithelia in vivo. This technique employs a wavelength dependent component of light Mie-scattered from epithelial cell nuclei to measure the size distribution of these nuclei. Since nuclear atypia is one of the hallmarks of precancerous and cancerous changes in most human tissues, the technique has the potential to provide a broadly applicable means of detecting epithelial precancerous lesions and noninvasive cancers in various organs which can be optically accessed either directly or by means of optical fibers. The results of in vivo human studies performed to test the potential of light scattering spectroscopy to diagnose precancerous lesions and early cancers in four organs (Barrett's esophagus, colon, bladder, and oral cavity) are presented.

Original language	English (US)
Pages (from-to)	255-263
Number of pages	9
Journal	Lasers in the Life Sciences
Volume	9
Issue number	4
State	Published - Jan 1 2001

Keywords

Barrett's Esophagial
Cancer detection
Cell nuclei
Dysplasia
Light scattering
Polarization
Refractive index
Spectroscopy

ASJC Scopus subject areas

Medicine (miscellaneous)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Backman, V., Wallace, M., Perelman, L. T., Arendt, J. T., Gurjar, R., Muller, M. G., Zhang, Q., Zonios, G., Kline, E., McGillican, T., Valdez, T., Van Dam, J., Badizadegan, K., Crawford, J. M., Fitzmaurice, M., Kabani, S., Levin, H. S., Seiler, M., Dasari, R. R., ... Feld, M. S. (2001). Light scattering spectroscopy: A new technique for clinical diagnosis of precancerous and cancerous changes in human epithelial tissues. Lasers in the Life Sciences, 9(4), 255-263.

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title = "Light scattering spectroscopy: A new technique for clinical diagnosis of precancerous and cancerous changes in human epithelial tissues",

abstract = "We present a light scattering spectroscopy based technique for detection of precancerous and early cancerous changes in human epithelia in vivo. This technique employs a wavelength dependent component of light Mie-scattered from epithelial cell nuclei to measure the size distribution of these nuclei. Since nuclear atypia is one of the hallmarks of precancerous and cancerous changes in most human tissues, the technique has the potential to provide a broadly applicable means of detecting epithelial precancerous lesions and noninvasive cancers in various organs which can be optically accessed either directly or by means of optical fibers. The results of in vivo human studies performed to test the potential of light scattering spectroscopy to diagnose precancerous lesions and early cancers in four organs (Barrett's esophagus, colon, bladder, and oral cavity) are presented.",

keywords = "Barrett's Esophagial, Cancer detection, Cell nuclei, Dysplasia, Light scattering, Polarization, Refractive index, Spectroscopy",

author = "V. Backman and M. Wallace and Perelman, {L. T.} and Arendt, {J. T.} and R. Gurjar and Muller, {M. G.} and Q. Zhang and G. Zonios and E. Kline and T. McGillican and T. Valdez and {Van Dam}, J. and K. Badizadegan and Crawford, {J. M.} and M. Fitzmaurice and S. Kabani and Levin, {H. S.} and M. Seiler and Dasari, {R. R.} and I. Itzkan and Feld, {M. S.}",

year = "2001",

month = jan,

day = "1",

language = "English (US)",

volume = "9",

pages = "255--263",

journal = "Lasers in the Life Sciences",

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Backman, V, Wallace, M, Perelman, LT, Arendt, JT, Gurjar, R, Muller, MG, Zhang, Q, Zonios, G, Kline, E, McGillican, T, Valdez, T, Van Dam, J, Badizadegan, K, Crawford, JM, Fitzmaurice, M, Kabani, S, Levin, HS, Seiler, M, Dasari, RR, Itzkan, I & Feld, MS 2001, 'Light scattering spectroscopy: A new technique for clinical diagnosis of precancerous and cancerous changes in human epithelial tissues', Lasers in the Life Sciences, vol. 9, no. 4, pp. 255-263.

TY - JOUR

T1 - Light scattering spectroscopy

T2 - A new technique for clinical diagnosis of precancerous and cancerous changes in human epithelial tissues

AU - Backman, V.

AU - Wallace, M.

AU - Perelman, L. T.

AU - Arendt, J. T.

AU - Gurjar, R.

AU - Muller, M. G.

AU - Zhang, Q.

AU - Zonios, G.

AU - Kline, E.

AU - McGillican, T.

AU - Valdez, T.

AU - Van Dam, J.

AU - Badizadegan, K.

AU - Crawford, J. M.

AU - Fitzmaurice, M.

AU - Kabani, S.

AU - Levin, H. S.

AU - Seiler, M.

AU - Dasari, R. R.

AU - Itzkan, I.

AU - Feld, M. S.

PY - 2001/1/1

Y1 - 2001/1/1

N2 - We present a light scattering spectroscopy based technique for detection of precancerous and early cancerous changes in human epithelia in vivo. This technique employs a wavelength dependent component of light Mie-scattered from epithelial cell nuclei to measure the size distribution of these nuclei. Since nuclear atypia is one of the hallmarks of precancerous and cancerous changes in most human tissues, the technique has the potential to provide a broadly applicable means of detecting epithelial precancerous lesions and noninvasive cancers in various organs which can be optically accessed either directly or by means of optical fibers. The results of in vivo human studies performed to test the potential of light scattering spectroscopy to diagnose precancerous lesions and early cancers in four organs (Barrett's esophagus, colon, bladder, and oral cavity) are presented.

AB - We present a light scattering spectroscopy based technique for detection of precancerous and early cancerous changes in human epithelia in vivo. This technique employs a wavelength dependent component of light Mie-scattered from epithelial cell nuclei to measure the size distribution of these nuclei. Since nuclear atypia is one of the hallmarks of precancerous and cancerous changes in most human tissues, the technique has the potential to provide a broadly applicable means of detecting epithelial precancerous lesions and noninvasive cancers in various organs which can be optically accessed either directly or by means of optical fibers. The results of in vivo human studies performed to test the potential of light scattering spectroscopy to diagnose precancerous lesions and early cancers in four organs (Barrett's esophagus, colon, bladder, and oral cavity) are presented.

KW - Barrett's Esophagial

KW - Cancer detection

KW - Cell nuclei

KW - Dysplasia

KW - Light scattering

KW - Polarization

KW - Refractive index

KW - Spectroscopy

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M3 - Article

AN - SCOPUS:0034840282

SN - 0886-0467

VL - 9

SP - 255

EP - 263

JO - Lasers in the Life Sciences

JF - Lasers in the Life Sciences

IS - 4

ER -

Light scattering spectroscopy: A new technique for clinical diagnosis of precancerous and cancerous changes in human epithelial tissues

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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