Light scattering spectroscopy: A new technique for clinical diagnosis of precancerous and cancerous changes in human epithelial tissues

V. Backman, M. Wallace, L. T. Perelman, J. T. Arendt, R. Gurjar, M. G. Muller, Q. Zhang, G. Zonios, E. Kline, T. McGillican, T. Valdez, J. Van Dam, K. Badizadegan, J. M. Crawford, M. Fitzmaurice, S. Kabani, H. S. Levin, M. Seiler, R. R. Dasari, I. ItzkanM. S. Feld*

*Corresponding author for this work

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

We present a light scattering spectroscopy based technique for detection of precancerous and early cancerous changes in human epithelia in vivo. This technique employs a wavelength dependent component of light Mie-scattered from epithelial cell nuclei to measure the size distribution of these nuclei. Since nuclear atypia is one of the hallmarks of precancerous and cancerous changes in most human tissues, the technique has the potential to provide a broadly applicable means of detecting epithelial precancerous lesions and noninvasive cancers in various organs which can be optically accessed either directly or by means of optical fibers. The results of in vivo human studies performed to test the potential of light scattering spectroscopy to diagnose precancerous lesions and early cancers in four organs (Barrett's esophagus, colon, bladder, and oral cavity) are presented.

Original languageEnglish (US)
Pages (from-to)255-263
Number of pages9
JournalLasers in the Life Sciences
Volume9
Issue number4
StatePublished - Jan 1 2001

Keywords

  • Barrett's Esophagial
  • Cancer detection
  • Cell nuclei
  • Dysplasia
  • Light scattering
  • Polarization
  • Refractive index
  • Spectroscopy

ASJC Scopus subject areas

  • Medicine (miscellaneous)

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    Backman, V., Wallace, M., Perelman, L. T., Arendt, J. T., Gurjar, R., Muller, M. G., Zhang, Q., Zonios, G., Kline, E., McGillican, T., Valdez, T., Van Dam, J., Badizadegan, K., Crawford, J. M., Fitzmaurice, M., Kabani, S., Levin, H. S., Seiler, M., Dasari, R. R., ... Feld, M. S. (2001). Light scattering spectroscopy: A new technique for clinical diagnosis of precancerous and cancerous changes in human epithelial tissues. Lasers in the Life Sciences, 9(4), 255-263.