Light through the fog: using precision fMRI data to disentangle the neural substrates of cognitive control

Derek M. Smith, Diana C. Perez, Alexis Porter, Ally Dworetsky, Caterina Gratton

Research output: Contribution to journalReview articlepeer-review

Abstract

Cognitive control, the ability to engage in goal-related behavior, is linked to frontal, parietal, and cingulate brain regions. However, the underlying function(s) of these regions is still in question, with ongoing discussions about their specificity and/or multifunctionality. These brain regions are also among the most variable across individuals, which may confound multi-functionality with inter-individual heterogeneity. Precision fMRI—extended data acquisition from single individuals—allows for reliable individualized mapping of brain organization. We review examples of recent studies that use precision fMRI to surmount inter-individual variability in functional neuroanatomy. These studies provide evidence of interleaved specialized and multifunctional regions in the frontal cortex. We discuss the potential for these techniques to address outstanding controversies on the neural underpinnings of cognitive control.

Original languageEnglish (US)
Pages (from-to)19-26
Number of pages8
JournalCurrent Opinion in Behavioral Sciences
Volume40
DOIs
StatePublished - Aug 2021

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Psychiatry and Mental health
  • Behavioral Neuroscience

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