LigSearch: A knowledge-based web server to identify likely ligands for a protein target

Tjaart A.P. De Beer, Roman A. Laskowski, Mark Eugene Duban, A. W. Edith Chan, Wayne F. Anderson, Janet M. Thornton*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Identifying which ligands might bind to a protein before crystallization trials could provide a significant saving in time and resources. LigSearch, a web server aimed at predicting ligands that might bind to and stabilize a given protein, has been developed. Using a protein sequence and/or structure, the system searches against a variety of databases, combining available knowledge, and provides a clustered and ranked output of possible ligands. LigSearch can be accessed at http://www.ebi.ac.uk/thornton-srv/databases/LigSearch.

Original languageEnglish (US)
Pages (from-to)2395-2402
Number of pages8
JournalActa Crystallographica Section D: Biological Crystallography
Volume69
Issue number12
DOIs
StatePublished - Dec 2013

Keywords

  • LigSearch
  • Ligand prediction

ASJC Scopus subject areas

  • Structural Biology

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