Limbal Stem Cell Transplantation

Merle Fernandes*, Virender S. Sangwan, Srinivas K. Rao, Surendra Basti, Mittanamalli S. Sridhar, Aashish K. Bansal, Harminder S. Dua

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

60 Scopus citations

Abstract

The past two decades have witnessed remarkable progress in limbal stem cell transplantation. In addition to harvesting stem cells from a cadaver or a live related donor, it is now possible to cultivate limbal stem cells in vitro and then transplant them onto the recipient bed. A clear understanding of the basic disease pathology and a correct assessment of the extent of stem cell deficiency are essential. A holistic approach towards management of limbal stem cell deficiency is needed. This also includes management of the underlying systemic disease, ocular adnexal pathology and dry eye. Conjunctival limbal autografts from the healthy contralateral eye are performed for unilateral cases. In bilateral cases, tissue may be harvested from a cadaver or a living related donor; prolonged immunosuppression is needed to avoid allograft rejection in such cases. This review describes the surgical techniques, postoperative treatment regimes (including immunosuppression for allografts), the complications and their management. The short and long-term outcomes of the various modalities reported in the literature are also described.

Original languageEnglish (US)
Pages (from-to)5-22
Number of pages18
JournalIndian journal of ophthalmology
Volume52
Issue number1
StatePublished - Mar 1 2004

ASJC Scopus subject areas

  • Ophthalmology

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