Limbic/mesolimbic connections and the pathogenesis of schizophrenia

John G. Csernansky*, Greer M. Murphy, William O. Faustman

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

105 Scopus citations


The development of models of the pathogenesis of neuropsychiatric diseases that build on recent advances in chemical neuroanatomy will help to guide future research. The interconnections among limbic, basal ganglia, and cortical structures are used to form the basis of a hypothesis of the pathogenesis of schizophrenia. The adaptive capacity of subcortical dopamine systems is advanced as an explanation of the many states of the disease.

Original languageEnglish (US)
Pages (from-to)383-400
Number of pages18
JournalBiological psychiatry
Issue number4
StatePublished - Aug 15 1991

ASJC Scopus subject areas

  • Biological Psychiatry


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