Limbic/mesolimbic connections and the pathogenesis of schizophrenia

John G. Csernansky; Greer M. Murphy; William O. Faustman

doi:10.1016/0006-3223(91)90295-W

Limbic/mesolimbic connections and the pathogenesis of schizophrenia

John G. Csernansky^*, Greer M. Murphy, William O. Faustman

^*Corresponding author for this work

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

106 Scopus citations

Abstract

The development of models of the pathogenesis of neuropsychiatric diseases that build on recent advances in chemical neuroanatomy will help to guide future research. The interconnections among limbic, basal ganglia, and cortical structures are used to form the basis of a hypothesis of the pathogenesis of schizophrenia. The adaptive capacity of subcortical dopamine systems is advanced as an explanation of the many states of the disease.

Original language	English (US)
Pages (from-to)	383-400
Number of pages	18
Journal	Biological psychiatry
Volume	30
Issue number	4
DOIs	https://doi.org/10.1016/0006-3223(91)90295-W
State	Published - Aug 15 1991

Funding

This workw as supportedi n part by a special granto f the MedicalR esearchS erviceo fthe VeteransA dministration (now Departmento f Veterans Affairs) to the Schizopl~'eniaB iologicR esearch Center (SBRC) at the Palo Alto VA Medical Center, and by grant MH30854 to the VA Stanford Mental Health Clinical Research Center at Stanford University. The authors that& Pamela J. Elliott for manuscript preparation and editorial advice.

ASJC Scopus subject areas

Biological Psychiatry

Access to Document

10.1016/0006-3223(91)90295-W

Cite this

@article{ad5a2ec629b74d0a80ffd84df92c3127,

title = "Limbic/mesolimbic connections and the pathogenesis of schizophrenia",

abstract = "The development of models of the pathogenesis of neuropsychiatric diseases that build on recent advances in chemical neuroanatomy will help to guide future research. The interconnections among limbic, basal ganglia, and cortical structures are used to form the basis of a hypothesis of the pathogenesis of schizophrenia. The adaptive capacity of subcortical dopamine systems is advanced as an explanation of the many states of the disease.",

author = "Csernansky, {John G.} and Murphy, {Greer M.} and Faustman, {William O.}",

note = "Funding Information: This workw as supportedi n part by a special granto f the MedicalR esearchS erviceo fthe VeteransA dministration (now Departmento f Veterans Affairs) to the Schizopl~'eniaB iologicR esearch Center (SBRC) at the Palo Alto VA Medical Center, and by grant MH30854 to the VA Stanford Mental Health Clinical Research Center at Stanford University. The authors that& Pamela J. Elliott for manuscript preparation and editorial advice.",

year = "1991",

month = aug,

day = "15",

doi = "10.1016/0006-3223(91)90295-W",

language = "English (US)",

volume = "30",

pages = "383--400",

journal = "Biological psychiatry",

issn = "0006-3223",

publisher = "Elsevier USA",

number = "4",

}

TY - JOUR

T1 - Limbic/mesolimbic connections and the pathogenesis of schizophrenia

AU - Csernansky, John G.

AU - Murphy, Greer M.

AU - Faustman, William O.

N1 - Funding Information: This workw as supportedi n part by a special granto f the MedicalR esearchS erviceo fthe VeteransA dministration (now Departmento f Veterans Affairs) to the Schizopl~'eniaB iologicR esearch Center (SBRC) at the Palo Alto VA Medical Center, and by grant MH30854 to the VA Stanford Mental Health Clinical Research Center at Stanford University. The authors that& Pamela J. Elliott for manuscript preparation and editorial advice.

PY - 1991/8/15

Y1 - 1991/8/15

N2 - The development of models of the pathogenesis of neuropsychiatric diseases that build on recent advances in chemical neuroanatomy will help to guide future research. The interconnections among limbic, basal ganglia, and cortical structures are used to form the basis of a hypothesis of the pathogenesis of schizophrenia. The adaptive capacity of subcortical dopamine systems is advanced as an explanation of the many states of the disease.

AB - The development of models of the pathogenesis of neuropsychiatric diseases that build on recent advances in chemical neuroanatomy will help to guide future research. The interconnections among limbic, basal ganglia, and cortical structures are used to form the basis of a hypothesis of the pathogenesis of schizophrenia. The adaptive capacity of subcortical dopamine systems is advanced as an explanation of the many states of the disease.

UR - http://www.scopus.com/inward/record.url?scp=0025812281&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025812281&partnerID=8YFLogxK

U2 - 10.1016/0006-3223(91)90295-W

DO - 10.1016/0006-3223(91)90295-W

M3 - Article

C2 - 1912130

AN - SCOPUS:0025812281

SN - 0006-3223

VL - 30

SP - 383

EP - 400

JO - Biological psychiatry

JF - Biological psychiatry

IS - 4

ER -

Limbic/mesolimbic connections and the pathogenesis of schizophrenia

Abstract

Funding

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this